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Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)

Christopher Nettle, L. Jenkins, Daniel Curtis Orcid Logo, Nafiseh Badiei, Keir Lewis Orcid Logo, Rhodri Williams Orcid Logo, Rob Daniels Orcid Logo

Biorheology, Volume: 54, Issue: 2-4, Pages: 67 - 80

Swansea University Authors: Christopher Nettle, Daniel Curtis Orcid Logo, Nafiseh Badiei, Keir Lewis Orcid Logo, Rhodri Williams Orcid Logo, Rob Daniels Orcid Logo

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DOI (Published version): 10.3233/BIR-17141

Abstract

Sputum samples from Chronic Obstructive Pulmonary Disease (COPD) patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM). The samples were all collected from patients within two days of their admission to Prince Philip Hospital due to an exacer...

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Published in: Biorheology
ISSN: 0006-355X 1878-5034
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa37591
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The samples were all collected from patients within two days of their admission to Prince Philip Hospital due to an exacerbation of their COPD. Oscillatory and creep rheological techniques were used to measure changes in viscoelastic properties at different frequencies over time, and COPD sputum was observed to behave as a viscoelastic solid at all frequencies studied. Comparing the rheology of exacerbated COPD sputum with healthy sputum (not diagnosed with a respiratory disease) revealed significant differences in response to oscillatory shear and creep-recovery experiments, which highlights the potential clinical benefits of better understanding sputum viscoelasticity. A common power law model G(t)=G0(t&#x3C4;0)&#x2212;m was successfully fitted to experimental rheology data over the range of frequencies studied. A comparison was made between clinical data and the power law index m obtained from rheology, which suggests that an important possible future application of this work is as a potential biomarker for COPD severity.</abstract><type>Journal Article</type><journal>Biorheology</journal><volume>54</volume><journalNumber>2-4</journalNumber><paginationStart>67</paginationStart><paginationEnd>80</paginationEnd><publisher/><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>0006-355X</issnPrint><issnElectronic>1878-5034</issnElectronic><keywords>Rheology, viscoelastic properties, Chronic Obstructive Pulmonary Disease</keywords><publishedDay>5</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-02-05</publishedDate><doi>10.3233/BIR-17141</doi><url/><notes/><college>COLLEGE NANME</college><department>Science and Engineering - Faculty</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>FGSEN</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-12-09T16:41:06.9821158</lastEdited><Created>2017-12-14T13:52:56.9024249</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemical Engineering</level></path><authors><author><firstname>Christopher</firstname><surname>Nettle</surname><order>1</order></author><author><firstname>L.</firstname><surname>Jenkins</surname><order>2</order></author><author><firstname>Daniel</firstname><surname>Curtis</surname><orcid>0000-0002-6955-0524</orcid><order>3</order></author><author><firstname>Nafiseh</firstname><surname>Badiei</surname><order>4</order></author><author><firstname>Keir</firstname><surname>Lewis</surname><orcid>0000-0002-8248-6774</orcid><order>5</order></author><author><firstname>Rhodri</firstname><surname>Williams</surname><orcid>0000-0002-6912-5288</orcid><order>6</order></author><author><firstname>Rob</firstname><surname>Daniels</surname><orcid>0000-0002-6933-8144</orcid><order>7</order></author></authors><documents><document><filename>0037591-14122017135453.pdf</filename><originalFilename>nettle2017.pdf</originalFilename><uploaded>2017-12-14T13:54:53.5930000</uploaded><type>Output</type><contentLength>2393078</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><embargoDate>2017-12-20T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-12-09T16:41:06.9821158 v2 37591 2017-12-14 Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD) 19395758f3317491d4c34eba6295893f Christopher Nettle Christopher Nettle true false e76ff28a23af2fe37099c4e9a24c1e58 0000-0002-6955-0524 Daniel Curtis Daniel Curtis true false c82cd1b82759801ab0045cb9f0047b06 Nafiseh Badiei Nafiseh Badiei true false bc53c343c975d6e0ad88c1d8b9ddd70c 0000-0002-8248-6774 Keir Lewis Keir Lewis true false 642bf793695f412ed932f1ea4d9bc3f1 0000-0002-6912-5288 Rhodri Williams Rhodri Williams true false 23f38c3bb732d4378986bdfaf7b6ee51 0000-0002-6933-8144 Rob Daniels Rob Daniels true false 2017-12-14 FGSEN Sputum samples from Chronic Obstructive Pulmonary Disease (COPD) patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM). The samples were all collected from patients within two days of their admission to Prince Philip Hospital due to an exacerbation of their COPD. Oscillatory and creep rheological techniques were used to measure changes in viscoelastic properties at different frequencies over time, and COPD sputum was observed to behave as a viscoelastic solid at all frequencies studied. Comparing the rheology of exacerbated COPD sputum with healthy sputum (not diagnosed with a respiratory disease) revealed significant differences in response to oscillatory shear and creep-recovery experiments, which highlights the potential clinical benefits of better understanding sputum viscoelasticity. A common power law model G(t)=G0(tτ0)−m was successfully fitted to experimental rheology data over the range of frequencies studied. A comparison was made between clinical data and the power law index m obtained from rheology, which suggests that an important possible future application of this work is as a potential biomarker for COPD severity. Journal Article Biorheology 54 2-4 67 80 0006-355X 1878-5034 Rheology, viscoelastic properties, Chronic Obstructive Pulmonary Disease 5 2 2018 2018-02-05 10.3233/BIR-17141 COLLEGE NANME Science and Engineering - Faculty COLLEGE CODE FGSEN Swansea University 2020-12-09T16:41:06.9821158 2017-12-14T13:52:56.9024249 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Christopher Nettle 1 L. Jenkins 2 Daniel Curtis 0000-0002-6955-0524 3 Nafiseh Badiei 4 Keir Lewis 0000-0002-8248-6774 5 Rhodri Williams 0000-0002-6912-5288 6 Rob Daniels 0000-0002-6933-8144 7 0037591-14122017135453.pdf nettle2017.pdf 2017-12-14T13:54:53.5930000 Output 2393078 application/pdf Accepted Manuscript true 2017-12-20T00:00:00.0000000 false eng
title Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
spellingShingle Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
Christopher Nettle
Daniel Curtis
Nafiseh Badiei
Keir Lewis
Rhodri Williams
Rob Daniels
title_short Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
title_full Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
title_fullStr Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
title_full_unstemmed Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
title_sort Linear rheology as a potential monitoring tool for sputum in patients with Chronic Obstructive Pulmonary Disease (COPD)
author_id_str_mv 19395758f3317491d4c34eba6295893f
e76ff28a23af2fe37099c4e9a24c1e58
c82cd1b82759801ab0045cb9f0047b06
bc53c343c975d6e0ad88c1d8b9ddd70c
642bf793695f412ed932f1ea4d9bc3f1
23f38c3bb732d4378986bdfaf7b6ee51
author_id_fullname_str_mv 19395758f3317491d4c34eba6295893f_***_Christopher Nettle
e76ff28a23af2fe37099c4e9a24c1e58_***_Daniel Curtis
c82cd1b82759801ab0045cb9f0047b06_***_Nafiseh Badiei
bc53c343c975d6e0ad88c1d8b9ddd70c_***_Keir Lewis
642bf793695f412ed932f1ea4d9bc3f1_***_Rhodri Williams
23f38c3bb732d4378986bdfaf7b6ee51_***_Rob Daniels
author Christopher Nettle
Daniel Curtis
Nafiseh Badiei
Keir Lewis
Rhodri Williams
Rob Daniels
author2 Christopher Nettle
L. Jenkins
Daniel Curtis
Nafiseh Badiei
Keir Lewis
Rhodri Williams
Rob Daniels
format Journal article
container_title Biorheology
container_volume 54
container_issue 2-4
container_start_page 67
publishDate 2018
institution Swansea University
issn 0006-355X
1878-5034
doi_str_mv 10.3233/BIR-17141
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Sputum samples from Chronic Obstructive Pulmonary Disease (COPD) patients were investigated using rheology, simple mathematical modelling and Scanning Electron Microscopy (SEM). The samples were all collected from patients within two days of their admission to Prince Philip Hospital due to an exacerbation of their COPD. Oscillatory and creep rheological techniques were used to measure changes in viscoelastic properties at different frequencies over time, and COPD sputum was observed to behave as a viscoelastic solid at all frequencies studied. Comparing the rheology of exacerbated COPD sputum with healthy sputum (not diagnosed with a respiratory disease) revealed significant differences in response to oscillatory shear and creep-recovery experiments, which highlights the potential clinical benefits of better understanding sputum viscoelasticity. A common power law model G(t)=G0(tτ0)−m was successfully fitted to experimental rheology data over the range of frequencies studied. A comparison was made between clinical data and the power law index m obtained from rheology, which suggests that an important possible future application of this work is as a potential biomarker for COPD severity.
published_date 2018-02-05T03:47:21Z
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