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Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease / Michael Lewis, Joe Annandale, Keir Lewis
Clinical Physiology and Functional Imaging, Volume: 29, Issue: 6, Pages: 431 - 439
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DOI (Published version): 10.1111/j.1475-097X.2009.00891.x
Influence of long-term oxygen therapy on heart rate and QT time-series in hypoxic patients with chronic obstructive pulmonary disease
|Published in:||Clinical Physiology and Functional Imaging|
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The novelty of this work was that it was the first to report cardiac benefits of long-term oxygen therapy (LTOT) in chronic obstructive pulmonary disease (COPD), demonstrated here through time-dependent reversal of autonomic nervous system depression. A rigorous pre-post clinical intervention study design and advanced time-series analysis methods provided evidence to support additional cardiac benefits of LTOT. The work led to further clinical collaborations to establish the cardio-pulmonary pathophysiology underlying COPD. This and companion works fostered the knowledge underpinning a major industrial collaboration with Haemair Ltd. (CIRP/A4B grant HE09COL1029) to empirically model a control system for an artificial lung device.
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