Journal article 341 views 121 downloads
Determination of prestress and elastic properties of virus capsids
Ankush Aggarwal 
Physical Review E, Volume: 97, Issue: 3
Swansea University Author:
Ankush Aggarwal
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DOI (Published version): 10.1103/PhysRevE.97.032414
Abstract
Virus capsids are protein shells which protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium s...
| Published in: | Physical Review E |
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| ISSN: | 2470-0045 2470-0053 |
| Published: |
2018
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa38941 |
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| Abstract: |
Virus capsids are protein shells which protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium state, due to their construction. These stresses, termed ``pre-stresses'' in this study, closely affect the capsid's mechanical behavior. Three methods --- shape-based metric, atomic force microscope indentation, and molecular dynamics --- have been proposed to determine the capsid elastic properties without fully accounting for pre-stresses. In this paper, we theoretically analyze the three methods used for mechanical characterization of virus capsids and numerically investigate how pre-stresses affect the capsid's mechanical properties. We consolidate all the results and propose that by using these techniques collectively, it is possible to accurately determine both the mechanical properties and pre-stresses in capsids. |
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| College: |
Faculty of Science and Engineering |
| Issue: |
3 |