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Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study / Alberto Coccarelli, Jason Carson, Hayder M. Hasan, Dimitris Parthimos, Perumal Nithiarasu

International Journal for Numerical Methods in Biomedical Engineering, Volume: 34, Issue: 10, Start page: e3120

Swansea University Authors: Alberto Coccarelli, Jason Carson, Perumal Nithiarasu

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DOI (Published version): 10.1002/cnm.3120

Abstract

Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced...

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Published in: International Journal for Numerical Methods in Biomedical Engineering
ISSN: 2040-7939
Published: Wiley 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa40698
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Abstract: Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced changes. The study outlines a framework for age‐related modifications within several interlinked subsystems, which include: arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration. Some of the proposed age‐dependent governing equations are directly extrapolated from experimental datasets. The computational framework is demonstrated through numerical experiments, which show the impact of such age‐related changes on arterial blood pressure, local temperature distribution, and global body thermal response. The proposed numerical experiments show that the age‐related changes in arterial convection do not significantly affect the tissue temperature distribution. Results also highlight age‐related effects on the sweating mechanism, which lead to a significant reduction in heat dissipation and a subsequent rise in skin and core temperatures.
Keywords: ageing, systemic circulation, bio‐heat transfer, thermoregulation, body thermal energy balance
College: College of Engineering
Issue: 10
Start Page: e3120