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Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study

Alberto Coccarelli Orcid Logo, Jason Carson Orcid Logo, Hayder M. Hasan, Dimitris Parthimos, Perumal Nithiarasu Orcid Logo

International Journal for Numerical Methods in Biomedical Engineering, Volume: 34, Issue: 10, Start page: e3120

Swansea University Authors: Alberto Coccarelli Orcid Logo, Jason Carson Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1002/cnm.3120

Abstract

Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced...

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Published in: International Journal for Numerical Methods in Biomedical Engineering
ISSN: 2040-7939
Published: Wiley 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa40698
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spelling 2020-07-31T14:19:26.5300619 v2 40698 2018-06-13 Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false c1f2c28fbe6a41c5134b45abde5abb93 0000-0001-6634-9123 Jason Carson Jason Carson true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2018-06-13 MECH Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced changes. The study outlines a framework for age‐related modifications within several interlinked subsystems, which include: arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration. Some of the proposed age‐dependent governing equations are directly extrapolated from experimental datasets. The computational framework is demonstrated through numerical experiments, which show the impact of such age‐related changes on arterial blood pressure, local temperature distribution, and global body thermal response. The proposed numerical experiments show that the age‐related changes in arterial convection do not significantly affect the tissue temperature distribution. Results also highlight age‐related effects on the sweating mechanism, which lead to a significant reduction in heat dissipation and a subsequent rise in skin and core temperatures. Journal Article International Journal for Numerical Methods in Biomedical Engineering 34 10 e3120 Wiley 2040-7939 ageing, systemic circulation, bio‐heat transfer, thermoregulation, body thermal energy balance 1 10 2018 2018-10-01 10.1002/cnm.3120 http://dx.doi.org/10.1002/cnm.3120 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2020-07-31T14:19:26.5300619 2018-06-13T10:18:21.1839005 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Jason Carson 0000-0001-6634-9123 2 Hayder M. Hasan 3 Dimitris Parthimos 4 Perumal Nithiarasu 0000-0002-4901-2980 5 0040698-14082018152644.pdf coccarelli2018(4).pdf 2018-08-14T15:26:44.8230000 Output 1163091 application/pdf Version of Record true 2018-08-14T00:00:00.0000000 Distributed under the terms of a Creative Commons Attribution (CC-BY) Licence. true eng https://creativecommons.org/licenses/by/4.0/
title Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
spellingShingle Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
Alberto Coccarelli
Jason Carson
Perumal Nithiarasu
title_short Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
title_full Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
title_fullStr Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
title_full_unstemmed Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
title_sort Influence of ageing on human body blood flow and heat transfer: A detailed computational modelling study
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
c1f2c28fbe6a41c5134b45abde5abb93
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
c1f2c28fbe6a41c5134b45abde5abb93_***_Jason Carson
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Alberto Coccarelli
Jason Carson
Perumal Nithiarasu
author2 Alberto Coccarelli
Jason Carson
Hayder M. Hasan
Dimitris Parthimos
Perumal Nithiarasu
format Journal article
container_title International Journal for Numerical Methods in Biomedical Engineering
container_volume 34
container_issue 10
container_start_page e3120
publishDate 2018
institution Swansea University
issn 2040-7939
doi_str_mv 10.1002/cnm.3120
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
url http://dx.doi.org/10.1002/cnm.3120
document_store_str 1
active_str 0
description Ageing plays a fundamental role in arterial blood transport and heat transfer within a human body. The aim of this work is to provide a comprehensive methodology, based on biomechanical considerations, for modelling arterial flow and energy exchange mechanisms in the body accounting for age‐induced changes. The study outlines a framework for age‐related modifications within several interlinked subsystems, which include: arterial stiffening, heart contractility variations, tissue volume and property changes, and thermoregulatory system deterioration. Some of the proposed age‐dependent governing equations are directly extrapolated from experimental datasets. The computational framework is demonstrated through numerical experiments, which show the impact of such age‐related changes on arterial blood pressure, local temperature distribution, and global body thermal response. The proposed numerical experiments show that the age‐related changes in arterial convection do not significantly affect the tissue temperature distribution. Results also highlight age‐related effects on the sweating mechanism, which lead to a significant reduction in heat dissipation and a subsequent rise in skin and core temperatures.
published_date 2018-10-01T03:51:48Z
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score 10.997933

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