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Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins. / Matthew D Hitchings
Swansea University Author: Matthew D Hitchings
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Abstract
The three DNA protection proteins from starved cells (Dps) of Streptomyces coelicolor are members of the min-ferritin super family. Considered to be of major importance to stress response systems in microorganisms. Dps proteins can aid microbial survival in extreme conditions. The S. coelicolor Dps...
| Published: |
2013
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| Institution: | Swansea University |
| Degree level: | Doctoral |
| Degree name: | Ph.D |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa42992 |
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| Abstract: |
The three DNA protection proteins from starved cells (Dps) of Streptomyces coelicolor are members of the min-ferritin super family. Considered to be of major importance to stress response systems in microorganisms. Dps proteins can aid microbial survival in extreme conditions. The S. coelicolor Dps proteins are not only induced in response to stress in a stimulus-dependent manner, but dual regulation allows these proteins to play a role in bacterial cell division; influencing condensation of nucleoids during spore formation. This study investigates the structural and functional properties of the ScDps proteins and finds multiple ways in which the homologs differ. (Abstract shortened.) |
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| Keywords: |
DNA, Streptomyces coelicolor, proteins |
| College: |
Faculty of Medicine, Health and Life Sciences |