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Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins. / Matthew D Hitchings

Swansea University Author: Matthew D Hitchings

Abstract

The three DNA protection proteins from starved cells (Dps) of Streptomyces coelicolor are members of the min-ferritin super family. Considered to be of major importance to stress response systems in microorganisms. Dps proteins can aid microbial survival in extreme conditions. The S. coelicolor Dps...

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Published: 2013
Institution: Swansea University
Degree level: Doctoral
Degree name: Ph.D
URI: https://cronfa.swan.ac.uk/Record/cronfa42992
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first_indexed 2018-08-02T18:56:02Z
last_indexed 2019-10-21T16:48:50Z
id cronfa42992
recordtype RisThesis
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spelling 2018-08-29T14:52:09.6760169 v2 42992 2018-08-02 Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins. fe8f448842c2d831a14a4f94cb3a4ffc NULL Matthew D Hitchings Matthew D Hitchings true true 2018-08-02 The three DNA protection proteins from starved cells (Dps) of Streptomyces coelicolor are members of the min-ferritin super family. Considered to be of major importance to stress response systems in microorganisms. Dps proteins can aid microbial survival in extreme conditions. The S. coelicolor Dps proteins are not only induced in response to stress in a stimulus-dependent manner, but dual regulation allows these proteins to play a role in bacterial cell division; influencing condensation of nucleoids during spore formation. This study investigates the structural and functional properties of the ScDps proteins and finds multiple ways in which the homologs differ. (Abstract shortened.) E-Thesis DNA, Streptomyces coelicolor, proteins 31 12 2013 2013-12-31 COLLEGE NANME Swansea University Medical School COLLEGE CODE Swansea University Doctoral Ph.D 2018-08-29T14:52:09.6760169 2018-08-02T16:24:30.9914044 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Matthew D Hitchings NULL 1 0042992-02082018162538.pdf 10821382.pdf 2018-08-02T16:25:38.1030000 Output 19420883 application/pdf E-Thesis true 2018-08-02T00:00:00.0000000 false
title Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
spellingShingle Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
Matthew D Hitchings
title_short Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
title_full Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
title_fullStr Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
title_full_unstemmed Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
title_sort Biochemical and structural analysis of the Streptomyces coelicolor Dps proteins.
author_id_str_mv fe8f448842c2d831a14a4f94cb3a4ffc
author_id_fullname_str_mv fe8f448842c2d831a14a4f94cb3a4ffc_***_Matthew D Hitchings
author Matthew D Hitchings
author2 Matthew D Hitchings
format E-Thesis
publishDate 2013
institution Swansea University
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description The three DNA protection proteins from starved cells (Dps) of Streptomyces coelicolor are members of the min-ferritin super family. Considered to be of major importance to stress response systems in microorganisms. Dps proteins can aid microbial survival in extreme conditions. The S. coelicolor Dps proteins are not only induced in response to stress in a stimulus-dependent manner, but dual regulation allows these proteins to play a role in bacterial cell division; influencing condensation of nucleoids during spore formation. This study investigates the structural and functional properties of the ScDps proteins and finds multiple ways in which the homologs differ. (Abstract shortened.)
published_date 2013-12-31T03:54:03Z
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score 11.036706

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