Journal article 1226 views
A multiscale framework for large deformation modeling of RBC membranes
Computer Methods in Applied Mechanics and Engineering, Volume: 329, Pages: 144 - 167
Swansea University Author:
Adesola Ademiloye
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1016/j.cma.2017.10.004
Abstract
In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relat...
Published in: | Computer Methods in Applied Mechanics and Engineering |
---|---|
ISSN: | 0045-7825 |
Published: |
Elsevier BV
2018
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa44904 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2018-10-16T13:47:48Z |
---|---|
last_indexed |
2020-07-01T19:00:09Z |
id |
cronfa44904 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2020-07-01T16:32:34.3096653</datestamp><bib-version>v2</bib-version><id>44904</id><entry>2018-10-16</entry><title>A multiscale framework for large deformation modeling of RBC membranes</title><swanseaauthors><author><sid>e37960ed89a7e3eaeba2201762626594</sid><ORCID>0000-0002-9741-6488</ORCID><firstname>Adesola</firstname><surname>Ademiloye</surname><name>Adesola Ademiloye</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2018-10-16</date><deptcode>MEDE</deptcode><abstract>In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane.</abstract><type>Journal Article</type><journal>Computer Methods in Applied Mechanics and Engineering</journal><volume>329</volume><paginationStart>144</paginationStart><paginationEnd>167</paginationEnd><publisher>Elsevier BV</publisher><issnPrint>0045-7825</issnPrint><keywords>Multiscale modeling, Cauchy–Born rule, Element-free method, IMLS-Ritz method, Nonlinear large deformation analysis, RBC membrane</keywords><publishedDay>1</publishedDay><publishedMonth>2</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-02-01</publishedDate><doi>10.1016/j.cma.2017.10.004</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-07-01T16:32:34.3096653</lastEdited><Created>2018-10-16T12:47:41.2917887</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>Adesola</firstname><surname>Ademiloye</surname><orcid>0000-0002-9741-6488</orcid><order>1</order></author><author><firstname>L.W.</firstname><surname>Zhang</surname><order>2</order></author><author><firstname>K.M.</firstname><surname>Liew</surname><order>3</order></author></authors><documents/><OutputDurs/></rfc1807> |
spelling |
2020-07-01T16:32:34.3096653 v2 44904 2018-10-16 A multiscale framework for large deformation modeling of RBC membranes e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane. Journal Article Computer Methods in Applied Mechanics and Engineering 329 144 167 Elsevier BV 0045-7825 Multiscale modeling, Cauchy–Born rule, Element-free method, IMLS-Ritz method, Nonlinear large deformation analysis, RBC membrane 1 2 2018 2018-02-01 10.1016/j.cma.2017.10.004 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2020-07-01T16:32:34.3096653 2018-10-16T12:47:41.2917887 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Adesola Ademiloye 0000-0002-9741-6488 1 L.W. Zhang 2 K.M. Liew 3 |
title |
A multiscale framework for large deformation modeling of RBC membranes |
spellingShingle |
A multiscale framework for large deformation modeling of RBC membranes Adesola Ademiloye |
title_short |
A multiscale framework for large deformation modeling of RBC membranes |
title_full |
A multiscale framework for large deformation modeling of RBC membranes |
title_fullStr |
A multiscale framework for large deformation modeling of RBC membranes |
title_full_unstemmed |
A multiscale framework for large deformation modeling of RBC membranes |
title_sort |
A multiscale framework for large deformation modeling of RBC membranes |
author_id_str_mv |
e37960ed89a7e3eaeba2201762626594 |
author_id_fullname_str_mv |
e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye |
author |
Adesola Ademiloye |
author2 |
Adesola Ademiloye L.W. Zhang K.M. Liew |
format |
Journal article |
container_title |
Computer Methods in Applied Mechanics and Engineering |
container_volume |
329 |
container_start_page |
144 |
publishDate |
2018 |
institution |
Swansea University |
issn |
0045-7825 |
doi_str_mv |
10.1016/j.cma.2017.10.004 |
publisher |
Elsevier BV |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
hierarchy_top_id |
facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
document_store_str |
0 |
active_str |
0 |
description |
In the present contribution, a multiscale framework for nonlinear analysis of finite deformation of red blood cell (RBC) membrane is developed. The first-order Cauchy–Born rule is adopted to establish an atomistic enriched hyperelastic constitutive model and to develop macroscale stress–strain relation of the RBC membrane. In order to circumvent the inherent limitations of utilizing mesh-based methods for large deformation analysis, we systematically coupled the 3D multiscale scheme with the element-free IMLS-Ritz method for numerical modeling of RBC deformability by simulating the optical tweezers experiment. This development was partly motivated by the need for a more precise scheme for modeling membrane structures. The effectiveness of the proposed approach is affirmed by the better prediction of RBC membrane deformability in comparison with experimental and numerical results found in literature and a significant reduction in computational cost. Our approach enables precise characterization of the effect of varying microstructure parameters, physiological, and osmolality conditions on the deformability of RBC membrane. |
published_date |
2018-02-01T03:56:23Z |
_version_ |
1763752839469858816 |
score |
11.021648 |