Conference Paper/Proceeding/Abstract 1256 views 200 downloads
Element-free multiscale modeling of large deformation behavior of red blood cell membrane with malaria infection
Proceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pages: 316 - 319
Swansea University Author:
Adesola Ademiloye
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DOI (Published version): 10.1101/136648
Abstract
In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they passthrough the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodiumfalciparum infection and maturation on the large deformation behavior of malaria-infected redblood cells (...
| Published in: | Proceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017) |
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| Published: |
Pittsburgh, Pennsylvania, USA
5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017)
2017
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| Online Access: |
http://www.compbiomed.net/getfile.php?type=13/site_documents&id=CMBE17Vol1prepress_2227-9385.pdf |
| URI: | https://cronfa.swan.ac.uk/Record/cronfa44908 |
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| Abstract: |
In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they passthrough the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodiumfalciparum infection and maturation on the large deformation behavior of malaria-infected redblood cells (iRBCs) by means of a three-dimensional (3D) multiscale meshfree method. Wenumerically simulated the optical tweezers experiment and observed the force-displacementresponse of the iRBC membrane as malaria infection progresses. Our simulation results agree well with experimental data and confirm that the deformability of malaria-infected cells decreasessignificantly as malaria infection progresses. |
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| Keywords: |
Red blood cell deformability, malaria infection, multiscale meshfree method |
| College: |
Faculty of Science and Engineering |
| Start Page: |
316 |
| End Page: |
319 |