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Conference Paper/Proceeding/Abstract 370 views 98 downloads

Element-free multiscale modeling of large deformation behavior of red blood cell membrane with malaria infection

A. S. Ademiloye, L. W. Zhang, K. M. Liew, Adesola Ademiloye Orcid Logo

Proceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pages: 316 - 319

Swansea University Author: Adesola Ademiloye Orcid Logo

DOI (Published version): 10.1101/136648

Abstract

In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they passthrough the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodiumfalciparum infection and maturation on the large deformation behavior of malaria-infected redblood cells (...

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Published in: Proceedings of the 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017)
Published: Pittsburgh, Pennsylvania, USA 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017) 2017
Online Access: http://www.compbiomed.net/getfile.php?type=13/site_documents&id=CMBE17Vol1prepress_2227-9385.pdf
URI: https://cronfa.swan.ac.uk/Record/cronfa44908
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Abstract: In normal physiological and healthy conditions, red blood cells (RBCs) deform readily as they passthrough the microcapillaries and the spleen. In this paper, we examine the effects of Plasmodiumfalciparum infection and maturation on the large deformation behavior of malaria-infected redblood cells (iRBCs) by means of a three-dimensional (3D) multiscale meshfree method. Wenumerically simulated the optical tweezers experiment and observed the force-displacementresponse of the iRBC membrane as malaria infection progresses. Our simulation results agree well with experimental data and confirm that the deformability of malaria-infected cells decreasessignificantly as malaria infection progresses.
Keywords: Red blood cell deformability, malaria infection, multiscale meshfree method
College: College of Engineering
Start Page: 316
End Page: 319