No Cover Image

Journal article 157 views

A three-dimensional quasicontinuum approach for predicting biomechanical properties of malaria-infected red blood cell membrane / Adesola, Ademiloye

Applied Mathematical Modelling, Volume: 49, Pages: 35 - 47

Swansea University Author: Adesola, Ademiloye

Full text not available from this repository: check for access using links below.

Abstract

This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the three-dimensional (3D) quasicontinuum approa...

Full description

Published in: Applied Mathematical Modelling
ISSN: 0307-904X
Published: Elsevier BV 2017
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa44906
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: This paper presents the first attempt to comprehensively estimate the elastic properties and mechanical responses of malaria-infected red blood cell (iRBC) membrane when subjected to uniaxial, shear and isotropic area-dilation loading conditions. With the three-dimensional (3D) quasicontinuum approach, we predicted the biomechanical properties of the iRBC membrane for all infection stages. Effect of temperature on the membrane elastic properties during the trophozoite stage was also examined. It is found that a multifold increase in the elastic properties of the iRBC membrane occurs as infection progresses. The axial, shear and area stiffnesses of the iRBC membrane increase exponentially, resulting in semi-logarithmic stress–strain relationship curves. In addition, the rigidity of the iRBC membrane in the trophozoite stage increases as temperature rise. It is concluded that Plasmodium falciparum parasites significantly affect the biomechanical properties of the RBC membrane due to the structural remodeling of the iRBC membrane microstructure.
Keywords: Plasmodium falciparum, Multiscale Cauchy–Born modeling, RBC membrane microstructure, Elastomechanical properties, Stress–strain curves, Temperature effect
College: College of Engineering
Start Page: 35
End Page: 47