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Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane

A. S. Ademiloye, L. W. Zhang, K. M. Liew, Adesola Ademiloye Orcid Logo

2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE)

Swansea University Author: Adesola Ademiloye Orcid Logo

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DOI (Published version): 10.1109/BIBE.2016.43

Abstract

From temperature conditions in blood storage units to those observed in patients with severe thermal burns, it is obvious that the human blood cells are subjected to various temperature ranges and conditions during their lifespan. It is also known that temperature affects the ability of blood cell t...

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Published in: 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE)
ISBN: 978-1-5090-3835-0 978-1-5090-3834-3
Published: Taichung, Taiwan 16th International Conference on Bioinformatics and Bioengineering (BIBE) 2016
URI: https://cronfa.swan.ac.uk/Record/cronfa44913
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first_indexed 2018-10-16T13:47:49Z
last_indexed 2018-11-12T20:22:11Z
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spelling 2018-11-12T14:52:05.6765858 v2 44913 2018-10-16 Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane e37960ed89a7e3eaeba2201762626594 0000-0002-9741-6488 Adesola Ademiloye Adesola Ademiloye true false 2018-10-16 MEDE From temperature conditions in blood storage units to those observed in patients with severe thermal burns, it is obvious that the human blood cells are subjected to various temperature ranges and conditions during their lifespan. It is also known that temperature affects the ability of blood cell to transverse thin microcapillaries, although the extent remains unknown. In this study, we employed a three-dimensional (3D) nonlinear multiscale meshfree approach to investigate the effects of freezing and heating temperatures on the deformability of the human red blood cell (RBC). The optical tweezers experiment was numerically simulated in order to quantify the deformability of red blood cells as a function of the relationship between its deformed axial and transverse diameter. We observe that the deformability of red blood cell membrane decreases as temperature increases. It is concluded that increase in temperature leads to increase in membrane rigidity and decrease in overall membrane deformability, which may be due to the denaturation of RBC membrane underlying cytoskeleton protein. Conference Paper/Proceeding/Abstract 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE) 16th International Conference on Bioinformatics and Bioengineering (BIBE) Taichung, Taiwan 978-1-5090-3835-0 978-1-5090-3834-3 31 12 2016 2016-12-31 10.1109/BIBE.2016.43 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2018-11-12T14:52:05.6765858 2018-10-16T12:47:52.3021934 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering A. S. Ademiloye 1 L. W. Zhang 2 K. M. Liew 3 Adesola Ademiloye 0000-0002-9741-6488 4
title Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
spellingShingle Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
Adesola Ademiloye
title_short Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
title_full Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
title_fullStr Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
title_full_unstemmed Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
title_sort Multiscale Meshfree Analysis of the Effects of Thermal Treatments on Deformability of Red Blood Cell Membrane
author_id_str_mv e37960ed89a7e3eaeba2201762626594
author_id_fullname_str_mv e37960ed89a7e3eaeba2201762626594_***_Adesola Ademiloye
author Adesola Ademiloye
author2 A. S. Ademiloye
L. W. Zhang
K. M. Liew
Adesola Ademiloye
format Conference Paper/Proceeding/Abstract
container_title 2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE)
publishDate 2016
institution Swansea University
isbn 978-1-5090-3835-0
978-1-5090-3834-3
doi_str_mv 10.1109/BIBE.2016.43
publisher 16th International Conference on Bioinformatics and Bioengineering (BIBE)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description From temperature conditions in blood storage units to those observed in patients with severe thermal burns, it is obvious that the human blood cells are subjected to various temperature ranges and conditions during their lifespan. It is also known that temperature affects the ability of blood cell to transverse thin microcapillaries, although the extent remains unknown. In this study, we employed a three-dimensional (3D) nonlinear multiscale meshfree approach to investigate the effects of freezing and heating temperatures on the deformability of the human red blood cell (RBC). The optical tweezers experiment was numerically simulated in order to quantify the deformability of red blood cells as a function of the relationship between its deformed axial and transverse diameter. We observe that the deformability of red blood cell membrane decreases as temperature increases. It is concluded that increase in temperature leads to increase in membrane rigidity and decrease in overall membrane deformability, which may be due to the denaturation of RBC membrane underlying cytoskeleton protein.
published_date 2016-12-31T03:56:24Z
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score 11.016235

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