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Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel

Francesco Del Giudice Orcid Logo, Gaetano D’Avino, Francesco Greco, Pier Luca Maffettone, Amy Q. Shen

Physical Review Applied, Volume: 10, Issue: 6

Swansea University Author: Francesco Del Giudice Orcid Logo

Abstract

Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel w...

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Published in: Physical Review Applied
ISSN: 2331-7019 2331-7019
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa46231
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spelling 2020-12-17T10:42:10.5998725 v2 46231 2018-12-05 Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel 742d483071479b44d7888e16166b1309 0000-0002-9414-6937 Francesco Del Giudice Francesco Del Giudice true false 2018-12-05 CHEG Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel walls can lead to blurred images and cell damage, thus negatively affecting applications related to flow cytometry. To address this challenge, we demonstrate that adding a tiny amount of hyaluronic acid biopolymer to an aqueous suspension drives self-assembly of a particle train on the centerline of a square-shaped straight microchannel, with a throughput up to approximately 2400 particles/s. The fraction of equally spaced particles increases by increasing the volumetric flow rate and the distance from the channel inlet. Numerical simulations corroborate the experimental observations and, together with a simple qualitative argument on the particle train stability, shed insights on the underlying mechanism leading to particle ordering. Journal Article Physical Review Applied 10 6 2331-7019 2331-7019 31 12 2018 2018-12-31 10.1103/PhysRevApplied.10.064058 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-12-17T10:42:10.5998725 2018-12-05T09:28:26.6557980 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Francesco Del Giudice 0000-0002-9414-6937 1 Gaetano D’Avino 2 Francesco Greco 3 Pier Luca Maffettone 4 Amy Q. Shen 5 0046231-05122018093712.pdf delgiudice2018.pdf 2018-12-05T09:37:12.4000000 Output 2434327 application/pdf Accepted Manuscript true 2018-12-05T00:00:00.0000000 true eng 0046231-06122018092756.pdf delgiudice2018supplementary.pdf 2018-12-06T09:27:56.0600000 Output 674605 application/pdf Supplemental material true 2018-12-06T00:00:00.0000000 true eng
title Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
spellingShingle Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
Francesco Del Giudice
title_short Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_full Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_fullStr Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_full_unstemmed Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_sort Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Francesco Del Giudice
author Francesco Del Giudice
author2 Francesco Del Giudice
Gaetano D’Avino
Francesco Greco
Pier Luca Maffettone
Amy Q. Shen
format Journal article
container_title Physical Review Applied
container_volume 10
container_issue 6
publishDate 2018
institution Swansea University
issn 2331-7019
2331-7019
doi_str_mv 10.1103/PhysRevApplied.10.064058
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel walls can lead to blurred images and cell damage, thus negatively affecting applications related to flow cytometry. To address this challenge, we demonstrate that adding a tiny amount of hyaluronic acid biopolymer to an aqueous suspension drives self-assembly of a particle train on the centerline of a square-shaped straight microchannel, with a throughput up to approximately 2400 particles/s. The fraction of equally spaced particles increases by increasing the volumetric flow rate and the distance from the channel inlet. Numerical simulations corroborate the experimental observations and, together with a simple qualitative argument on the particle train stability, shed insights on the underlying mechanism leading to particle ordering.
published_date 2018-12-31T03:52:26Z
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