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Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel / Francesco Del Giudice; Gaetano D’Avino; Francesco Greco; Pier Luca Maffettone; Amy Q. Shen

Physical Review Applied, Volume: 10, Issue: 6

Swansea University Author: Del Giudice, Francesco

Abstract

Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel w...

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Published in: Physical Review Applied
ISSN: 2331-7019
Published: 2018
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URI: https://cronfa.swan.ac.uk/Record/cronfa46231
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spelling 2019-03-19T17:36:23Z v2 46231 2018-12-05 Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel Francesco Del Giudice Francesco Del Giudice true 0000-0002-9414-6937 false 742d483071479b44d7888e16166b1309 abda2782a1cfe7064061eb2ebe561f6d qh5LBBaIf79wYrUsa0Eg9ikEU4Wnjmyk/K1JV06j1+mdoT9A3fdnqfQd9RTbbnkb 2018-12-05 EEN Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel walls can lead to blurred images and cell damage, thus negatively affecting applications related to flow cytometry. To address this challenge, we demonstrate that adding a tiny amount of hyaluronic acid biopolymer to an aqueous suspension drives self-assembly of a particle train on the centerline of a square-shaped straight microchannel, with a throughput up to approximately 2400 particles/s. The fraction of equally spaced particles increases by increasing the volumetric flow rate and the distance from the channel inlet. Numerical simulations corroborate the experimental observations and, together with a simple qualitative argument on the particle train stability, shed insights on the underlying mechanism leading to particle ordering. Journal article Physical Review Applied 10 6 2331-7019 0 12 2018 2018-12-01 10.1103/PhysRevApplied.10.064058 College of Engineering Engineering CENG EEN None None 2019-03-19T17:36:23Z 2018-12-05T09:28:26Z College of Engineering Engineering Francesco Del Giudice 1 Gaetano D’Avino 2 Francesco Greco 3 Pier Luca Maffettone 4 Amy Q. Shen 5 0046231-05122018093712.pdf delgiudice2018.pdf 2018-12-05T09:37:12Z Output 2434327 application/pdf AM true Updated Copyright 22/01/2019 2018-12-05T00:00:00 true eng 0046231-06122018092756.pdf delgiudice2018supplementary.pdf 2018-12-06T09:27:56Z Output 674605 application/pdf AM true Updated Notes 22/01/2019 2018-12-06T00:00:00 Supplementary information. true eng
title Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
spellingShingle Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
Del Giudice, Francesco
title_short Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_full Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_fullStr Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_full_unstemmed Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
title_sort Fluid Viscoelasticity Drives Self-Assembly of Particle Trains in a Straight Microfluidic Channel
author_id_str_mv 742d483071479b44d7888e16166b1309
author_id_fullname_str_mv 742d483071479b44d7888e16166b1309_***_Del Giudice, Francesco
author Del Giudice, Francesco
author2 Francesco Del Giudice
Gaetano D’Avino
Francesco Greco
Pier Luca Maffettone
Amy Q. Shen
format Journal article
container_title Physical Review Applied
container_volume 10
container_issue 6
publishDate 2018
institution Swansea University
issn 2331-7019
doi_str_mv 10.1103/PhysRevApplied.10.064058
college_str College of Engineering
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hierarchy_top_id collegeofengineering
hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
document_store_str 1
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description Strings of equally spaced particles (particle train) are tremendously important in a variety of microfluidic applications. By using inertial microfluidics, particle trains can be formed near the channel walls. However, the high particle rotation and large local shear gradient near the microchannel walls can lead to blurred images and cell damage, thus negatively affecting applications related to flow cytometry. To address this challenge, we demonstrate that adding a tiny amount of hyaluronic acid biopolymer to an aqueous suspension drives self-assembly of a particle train on the centerline of a square-shaped straight microchannel, with a throughput up to approximately 2400 particles/s. The fraction of equally spaced particles increases by increasing the volumetric flow rate and the distance from the channel inlet. Numerical simulations corroborate the experimental observations and, together with a simple qualitative argument on the particle train stability, shed insights on the underlying mechanism leading to particle ordering.
published_date 2018-12-01T04:51:33Z
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score 10.79785