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Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients / William Griffiths; Jonas Abdel-Khalik; Eylan Yutuc; Gustavo Roman; Margaret Warner; Jan-Åke Gustafsson; Yuqin Wang

Free Radical Biology and Medicine, Volume: 134, Pages: 42 - 52

Swansea University Authors: William, Griffiths, Eylan, Yutuc

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Abstract

Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodi...

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Published in: Free Radical Biology and Medicine
ISSN: 08915849
Published: 2019
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa48010
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Abstract: Using liquid chromatography – mass spectrometry in combination with derivatisation chemistry we profiled the oxysterol and cholestenoic acid content of cerebrospinal fluid from patients with Alzheimer’s disease (n = 21), vascular dementia (n = 11), other neurodegenerative diseases (n = 15, Lewy bodies dementia, n = 3, Frontotemporal dementia, n = 11) and controls (n = 15). Thirty different sterols were quantified and the bile acid precursor 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acid found to be reduced in abundance in cerebrospinal fluid of Alzheimer’s disease patient-group. This was the only sterol found to be changed amongst the different groups.
Keywords: Sterol; Cholesterol; Oxysterol; Cholestenoic acid; Bile acid; Brain; Neurodegenerative disease; Mass spectrometry, Cytochrome P450.
College: Swansea University Medical School
Start Page: 42
End Page: 52