No Cover Image

Journal article 84 views

Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance / Ilyas, Khan

The Journal of Hand Surgery (Asian-Pacific Volume), Volume: 23, Issue: 04, Pages: 463 - 468

Swansea University Author: Ilyas, Khan

Full text not available from this repository: check for access using links below.

Abstract

BACKGROUND:Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the...

Full description

Published in: The Journal of Hand Surgery (Asian-Pacific Volume)
ISSN: 2424-8355 2424-8363
Published: 2018
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa49768
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2019-03-27T11:22:14Z
last_indexed 2019-04-09T13:04:30Z
id cronfa49768
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-04-08T16:02:09.8575860</datestamp><bib-version>v2</bib-version><id>49768</id><entry>2019-03-27</entry><title>Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance</title><swanseaauthors><author><sid>2536d955ff70e7b77063a8efe9103161</sid><ORCID>0000-0002-3886-1987</ORCID><firstname>Ilyas</firstname><surname>Khan</surname><name>Ilyas Khan</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-03-27</date><deptcode>BMS</deptcode><abstract>BACKGROUND:Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the most pivotal groups of mediators that are crucial to the healing process are growth factors (GF). Intense pulse light (IPL) can lead to evidence of new collagen formation with associated clinical improvement in tissue healing. The biological benefit of Intense pulse light (IPL) relies on judicious photothermolysis, where heat driven radiation is dissipated and focused at the cellular level. The aims of this study is to set out the effect of growth factor and IPL on healing following a tendon repair.METHODS:Bovine common digital extensor tendons (CDET) were used as an ex vivo model. 44 tendon repairs were performed by the lead author using 2.5 &#xD7; magnification loupes and standard instruments. Clamped tendons were assigned into the following groups; control, IPL, GF, IPL and GF. After culturing, biomechanical testing was carried out using monotonic tensile testing with displacement-controlled uniaxial tension to failure.RESULTS:The mean values for ultimate tensile stress (UTS) for the control group was 53.51 N, for IPL it was 51.15 N, for growth factor was 70.10 N and for combined growth factor and IPL it was 75.16 N.CONCLUSIONS:This study showed significant improvement in UTS when repaired tendons were cultured with growth factor compared to control and IPL. This would suggest a biomechanical advantage for tendon healing.</abstract><type>Journal Article</type><journal>The Journal of Hand Surgery (Asian-Pacific Volume)</journal><volume>23</volume><journalNumber>04</journalNumber><paginationStart>463</paginationStart><paginationEnd>468</paginationEnd><publisher/><issnPrint>2424-8355</issnPrint><issnElectronic>2424-8363</issnElectronic><keywords>Biomechanical; Growth factor; Healing; Tendon</keywords><publishedDay>1</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2018</publishedYear><publishedDate>2018-12-01</publishedDate><doi>10.1142/S2424835518500431</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>BMS</DepartmentCode><institution>Swansea University</institution><lastEdited>2019-04-08T16:02:09.8575860</lastEdited><Created>2019-03-27T09:10:12.5131967</Created><path><level id="1">Swansea University Medical School</level><level id="2">Medicine</level></path><authors><author><firstname>Ilyas</firstname><surname>Khan</surname><orcid>0000-0002-3886-1987</orcid><order>1</order></author></authors><documents/></rfc1807>
spelling 2019-04-08T16:02:09.8575860 v2 49768 2019-03-27 Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance 2536d955ff70e7b77063a8efe9103161 0000-0002-3886-1987 Ilyas Khan Ilyas Khan true false 2019-03-27 BMS BACKGROUND:Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the most pivotal groups of mediators that are crucial to the healing process are growth factors (GF). Intense pulse light (IPL) can lead to evidence of new collagen formation with associated clinical improvement in tissue healing. The biological benefit of Intense pulse light (IPL) relies on judicious photothermolysis, where heat driven radiation is dissipated and focused at the cellular level. The aims of this study is to set out the effect of growth factor and IPL on healing following a tendon repair.METHODS:Bovine common digital extensor tendons (CDET) were used as an ex vivo model. 44 tendon repairs were performed by the lead author using 2.5 × magnification loupes and standard instruments. Clamped tendons were assigned into the following groups; control, IPL, GF, IPL and GF. After culturing, biomechanical testing was carried out using monotonic tensile testing with displacement-controlled uniaxial tension to failure.RESULTS:The mean values for ultimate tensile stress (UTS) for the control group was 53.51 N, for IPL it was 51.15 N, for growth factor was 70.10 N and for combined growth factor and IPL it was 75.16 N.CONCLUSIONS:This study showed significant improvement in UTS when repaired tendons were cultured with growth factor compared to control and IPL. This would suggest a biomechanical advantage for tendon healing. Journal Article The Journal of Hand Surgery (Asian-Pacific Volume) 23 04 463 468 2424-8355 2424-8363 Biomechanical; Growth factor; Healing; Tendon 1 12 2018 2018-12-01 10.1142/S2424835518500431 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University 2019-04-08T16:02:09.8575860 2019-03-27T09:10:12.5131967 Swansea University Medical School Medicine Ilyas Khan 0000-0002-3886-1987 1
title Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
spellingShingle Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
Ilyas, Khan
title_short Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
title_full Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
title_fullStr Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
title_full_unstemmed Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
title_sort Growth Factor and Intense Pulse Light in Flexor Tendon Repair: A Biomechanical Study at Strength and Gap Resistance
author_id_str_mv 2536d955ff70e7b77063a8efe9103161
author_id_fullname_str_mv 2536d955ff70e7b77063a8efe9103161_***_Ilyas, Khan
author Ilyas, Khan
format Journal article
container_title The Journal of Hand Surgery (Asian-Pacific Volume)
container_volume 23
container_issue 04
container_start_page 463
publishDate 2018
institution Swansea University
issn 2424-8355
2424-8363
doi_str_mv 10.1142/S2424835518500431
college_str Swansea University Medical School
hierarchytype
hierarchy_top_id swanseauniversitymedicalschool
hierarchy_top_title Swansea University Medical School
hierarchy_parent_id swanseauniversitymedicalschool
hierarchy_parent_title Swansea University Medical School
department_str Medicine{{{_:::_}}}Swansea University Medical School{{{_:::_}}}Medicine
document_store_str 0
active_str 0
description BACKGROUND:Flexor tendon injuries are extremely common and they are usually the result of incised traumatic glass or knife injury. The process of tendon healing is a complicated and exceptionally-regimented mechanism that is originated and monitored by a vast number of diverse molecules. One of the most pivotal groups of mediators that are crucial to the healing process are growth factors (GF). Intense pulse light (IPL) can lead to evidence of new collagen formation with associated clinical improvement in tissue healing. The biological benefit of Intense pulse light (IPL) relies on judicious photothermolysis, where heat driven radiation is dissipated and focused at the cellular level. The aims of this study is to set out the effect of growth factor and IPL on healing following a tendon repair.METHODS:Bovine common digital extensor tendons (CDET) were used as an ex vivo model. 44 tendon repairs were performed by the lead author using 2.5 × magnification loupes and standard instruments. Clamped tendons were assigned into the following groups; control, IPL, GF, IPL and GF. After culturing, biomechanical testing was carried out using monotonic tensile testing with displacement-controlled uniaxial tension to failure.RESULTS:The mean values for ultimate tensile stress (UTS) for the control group was 53.51 N, for IPL it was 51.15 N, for growth factor was 70.10 N and for combined growth factor and IPL it was 75.16 N.CONCLUSIONS:This study showed significant improvement in UTS when repaired tendons were cultured with growth factor compared to control and IPL. This would suggest a biomechanical advantage for tendon healing.
published_date 2018-12-01T19:10:52Z
_version_ 1649933761743159296
score 10.866461