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Modelling accidental hypothermia effects on a human body under different pathophysiological conditions

Alberto Coccarelli Orcid Logo, Etienne Boileau, Dimitris Parthimos, Perumal Nithiarasu Orcid Logo

Medical & Biological Engineering & Computing, Volume: 55, Issue: 12, Pages: 2155 - 2167

Swansea University Authors: Alberto Coccarelli Orcid Logo, Perumal Nithiarasu Orcid Logo

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DOI (Published version): 10.1007/s11517-017-1657-3

Abstract

Accidental exposure to cold water environment is one of the most challenging situations in which hypothermia occurs. In the present work, we aim to characterise the energy balance of a human body subjected to such extreme environmental conditions. This study is carried out using a recently developed...

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Published in: Medical & Biological Engineering & Computing
ISSN: 0140-0118 1741-0444
Published: 2017
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URI: https://cronfa.swan.ac.uk/Record/cronfa49823
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last_indexed 2020-06-29T19:02:32Z
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spelling 2020-06-29T15:30:05.0773585 v2 49823 2019-03-29 Modelling accidental hypothermia effects on a human body under different pathophysiological conditions 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2019-03-29 MECH Accidental exposure to cold water environment is one of the most challenging situations in which hypothermia occurs. In the present work, we aim to characterise the energy balance of a human body subjected to such extreme environmental conditions. This study is carried out using a recently developed computational model and by setting boundary conditions needed to simulate the effect of cold surrounding environment. A major finding is the capacity of the body core regions to maintain their temperature high for a substantial amount of time, even under the most extreme environmental conditions. We also considered two disease states that highlight the spectrum of possible pathologies implicated in thermal regulation of the human body. These states are (i) cardiomyopathy, which affects the operating capacity of the heart, and (ii) malnutrition, which directly impairs the body’s ability to regulate heat exchange with the environment. We have found that cardiomyopathy has little influence on the thermal balance of the human body, whereas malnutrition has a profound negative effect on the thermal balance and leads to dramatic reduction in core temperature. Journal Article Medical & Biological Engineering & Computing 55 12 2155 2167 0140-0118 1741-0444 Hypothermia modelling, Bio-heat transfer, Thermoregulation, Cardiomyopathy, Malnutrition 31 12 2017 2017-12-31 10.1007/s11517-017-1657-3 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2020-06-29T15:30:05.0773585 2019-03-29T18:22:32.6225072 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Etienne Boileau 2 Dimitris Parthimos 3 Perumal Nithiarasu 0000-0002-4901-2980 4 49823__13317__e9aaa23ce99a4acfbe1e7868689885b3.pdf coccarelli2017v2.pdf 2019-04-01T15:26:09.5770000 Output 4930396 application/pdf Version of Record true 2019-04-01T00:00:00.0000000 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
spellingShingle Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
Alberto Coccarelli
Perumal Nithiarasu
title_short Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
title_full Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
title_fullStr Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
title_full_unstemmed Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
title_sort Modelling accidental hypothermia effects on a human body under different pathophysiological conditions
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto Coccarelli
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal Nithiarasu
author Alberto Coccarelli
Perumal Nithiarasu
author2 Alberto Coccarelli
Etienne Boileau
Dimitris Parthimos
Perumal Nithiarasu
format Journal article
container_title Medical & Biological Engineering & Computing
container_volume 55
container_issue 12
container_start_page 2155
publishDate 2017
institution Swansea University
issn 0140-0118
1741-0444
doi_str_mv 10.1007/s11517-017-1657-3
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Civil Engineering
document_store_str 1
active_str 0
description Accidental exposure to cold water environment is one of the most challenging situations in which hypothermia occurs. In the present work, we aim to characterise the energy balance of a human body subjected to such extreme environmental conditions. This study is carried out using a recently developed computational model and by setting boundary conditions needed to simulate the effect of cold surrounding environment. A major finding is the capacity of the body core regions to maintain their temperature high for a substantial amount of time, even under the most extreme environmental conditions. We also considered two disease states that highlight the spectrum of possible pathologies implicated in thermal regulation of the human body. These states are (i) cardiomyopathy, which affects the operating capacity of the heart, and (ii) malnutrition, which directly impairs the body’s ability to regulate heat exchange with the environment. We have found that cardiomyopathy has little influence on the thermal balance of the human body, whereas malnutrition has a profound negative effect on the thermal balance and leads to dramatic reduction in core temperature.
published_date 2017-12-31T04:01:03Z
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score 10.998093

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