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Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices / Matthew, Burton

ACS Nano

Swansea University Author: Matthew, Burton

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Abstract

DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we dem...

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Published in: ACS Nano
ISSN: 1936-0851 1936-086X
Published: American Chemical Society 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa50091
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spelling 2019-07-17T11:48:48.0081126 v2 50091 2019-04-25 Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices 2deade2806e39b1f749e9cf67ac640b2 0000-0002-0376-6322 Matthew Burton Matthew Burton true false 2019-04-25 EEN DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. The oligonucleotides attached to the nanoparticles are encoded to ligate using 365 nm light, effectively locking the SLs and rendering them stable under DNA denaturing conditions. The reversible process of unlocking these structures is possible by irradiation with light at 315 nm, recovering the structures to their natural state. Our work inspires an alternative research direction toward postassembly manipulation of nanoparticle superstructures using external stimuli as a tool to enrich the library of additional material forms and their application in different media and environments. Journal Article ACS Nano American Chemical Society 1936-0851 1936-086X DNA, nanoparticles, photochemical ligation, self-assembly, superlattices 8 4 2019 2019-04-08 10.1021/acsnano.9b01294 https://pubs.acs.org/doi/abs/10.1021/acsnano.9b01294 COLLEGE NANME Engineering COLLEGE CODE EEN Swansea University 2019-07-17T11:48:48.0081126 2019-04-25T10:35:21.6526833 College of Engineering Engineering Angela F. De Fazio 1 Afaf H. El-Sagheer 2 Jason S. Kahn 3 Iris Nandhakumar 4 Matthew Burton 0000-0002-0376-6322 5 Tom Brown 6 Otto L. Muskens 7 Oleg Gang 8 Antonios G. Kanaras 9 0050091-25042019151752.docx Light-inducedreversibleDNAligationofgoldnanoparticlesuperlattices.docx 2019-04-25T15:17:52.6330000 Output 2697036 application/vnd.openxmlformats-officedocument.wordprocessingml.document Accepted Manuscript true 2020-04-01T00:00:00.0000000 This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Nano, copyright © American Chemical Society after peer review. To access the final edited and published work see https://pubs.acs.org/doi/abs/10.1021/acsnano.9b01294. true eng 0050091-13052019132226.pdf defazio2-19(2).pdf 2019-05-13T13:22:26.8170000 Output 7219931 application/pdf Version of Record true 2019-05-13T00:00:00.0000000 Distributed under the terms of a Creative Commons Attribution (CC-BY-4.0) true eng
title Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
spellingShingle Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
Matthew, Burton
title_short Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
title_full Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
title_fullStr Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
title_full_unstemmed Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
title_sort Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices
author_id_str_mv 2deade2806e39b1f749e9cf67ac640b2
author_id_fullname_str_mv 2deade2806e39b1f749e9cf67ac640b2_***_Matthew, Burton
author Matthew, Burton
format Journal article
container_title ACS Nano
publishDate 2019
institution Swansea University
issn 1936-0851
1936-086X
doi_str_mv 10.1021/acsnano.9b01294
publisher American Chemical Society
college_str College of Engineering
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hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
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url https://pubs.acs.org/doi/abs/10.1021/acsnano.9b01294
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description DNA-mediated self-assembly of nanoparticles has been of great interest because it enables access to nanoparticle superstructures that cannot be synthesized otherwise. However, the programmability of higher order nanoparticle structures can be easily lost under DNA denaturing conditions. Here, we demonstrate that light can be employed as an external stimulus to master the stability of nanoparticle superlattices (SLs) via the promotion of a reversible photoligation of DNA in SLs. The oligonucleotides attached to the nanoparticles are encoded to ligate using 365 nm light, effectively locking the SLs and rendering them stable under DNA denaturing conditions. The reversible process of unlocking these structures is possible by irradiation with light at 315 nm, recovering the structures to their natural state. Our work inspires an alternative research direction toward postassembly manipulation of nanoparticle superstructures using external stimuli as a tool to enrich the library of additional material forms and their application in different media and environments.
published_date 2019-04-08T04:12:55Z
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