Journal article 458 views
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review
F. L. Game,
J. Apelqvist,
C. Attinger,
A. Hartemann,
R. J. Hinchliffe,
M. Löndahl,
P. E. Price,
W. J. Jeffcoate,
Tricia Price
Diabetes/Metabolism Research and Reviews, Volume: 32, Pages: 154 - 168
Swansea University Author: Tricia Price
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DOI (Published version): 10.1002/dmrr.2707
Abstract
The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing publ...
Published in: | Diabetes/Metabolism Research and Reviews |
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ISSN: | 15207552 |
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2016
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URI: | https://cronfa.swan.ac.uk/Record/cronfa50577 |
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v2 50577 2019-05-30 Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review 72b4943af96c97ef72977c31b9c29624 Tricia Price Tricia Price true false 2019-05-30 FGMHL The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas, which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between June 2010 and June 2014. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae or hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; oxygen and other gases, compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound and other systemic therapies, which did not fit in the aforementioned categories. Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papers identified, 30 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic reviews, and the conclusion is similar: that with the possible exception of negative pressure wound therapy in post‐operative wounds, there is little published evidence to justify the use of newer therapies. Analysis of the evidence continues to present difficulties in this field as controlled studies remain few and the majority continue to be of poor methodological quality. Journal Article Diabetes/Metabolism Research and Reviews 32 154 168 15207552 31 12 2016 2016-12-31 10.1002/dmrr.2707 COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University 2023-06-28T15:27:49.4087814 2019-05-30T16:11:24.3112587 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine F. L. Game 1 J. Apelqvist 2 C. Attinger 3 A. Hartemann 4 R. J. Hinchliffe 5 M. Löndahl 6 P. E. Price 7 W. J. Jeffcoate 8 Tricia Price 9 |
title |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
spellingShingle |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review Tricia Price |
title_short |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
title_full |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
title_fullStr |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
title_full_unstemmed |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
title_sort |
Effectiveness of interventions to enhance healing of chronic ulcers of the foot in diabetes: a systematic review |
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72b4943af96c97ef72977c31b9c29624 |
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72b4943af96c97ef72977c31b9c29624_***_Tricia Price |
author |
Tricia Price |
author2 |
F. L. Game J. Apelqvist C. Attinger A. Hartemann R. J. Hinchliffe M. Löndahl P. E. Price W. J. Jeffcoate Tricia Price |
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Diabetes/Metabolism Research and Reviews |
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32 |
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154 |
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2016 |
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15207552 |
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10.1002/dmrr.2707 |
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Faculty of Medicine, Health and Life Sciences |
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Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine |
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description |
The outcome of management of diabetic foot ulcers remains a challenge, and there remains continuing uncertainty concerning optimal approaches to management. It is for these reasons that in 2008 and 2012, the International Working Group of the Diabetic Foot (IWGDF) working group on wound healing published systematic reviews of the evidence to inform protocols for routine care and to highlight areas, which should be considered for further study. The same working group has now updated this review by considering papers on the interventions to improve the healing of chronic ulcers published between June 2010 and June 2014. Methodological quality of selected studies was independently assessed by two reviewers using Scottish Intercollegiate Guidelines Network criteria. Selected studies fell into the following ten categories: sharp debridement and wound bed preparation with larvae or hydrotherapy; wound bed preparation using antiseptics, applications and dressing products; resection of the chronic wound; oxygen and other gases, compression or negative pressure therapy; products designed to correct aspects of wound biochemistry and cell biology associated with impaired wound healing; application of cells, including platelets and stem cells; bioengineered skin and skin grafts; electrical, electromagnetic, lasers, shockwaves and ultrasound and other systemic therapies, which did not fit in the aforementioned categories. Heterogeneity of studies prevented pooled analysis of results. Of the 2161 papers identified, 30 were selected for grading following full text review. The present report is an update of the earlier IWGDF systematic reviews, and the conclusion is similar: that with the possible exception of negative pressure wound therapy in post‐operative wounds, there is little published evidence to justify the use of newer therapies. Analysis of the evidence continues to present difficulties in this field as controlled studies remain few and the majority continue to be of poor methodological quality. |
published_date |
2016-12-31T15:27:45Z |
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1769956930270265344 |
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11.021648 |