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The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina / Sarah, Prior; Rachel, Churm

Journal of Diabetes & Metabolism, Volume: 7, Issue: 7

Swansesa University Authors: Sarah, Prior, Rachel, Churm, Rachel, Churm, Rachel, Churm, Rachel, Churm

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Abstract

Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter...

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Published in: Journal of Diabetes & Metabolism
ISSN: 21556156
Published: 2016
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URI: https://cronfa.swan.ac.uk/Record/cronfa50671
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spelling 2019-06-18T08:52:51.6958150 v2 50671 2019-06-06 The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina cdda101035997acfaa6fdf17097f52b2 0000-0001-8703-8092 Sarah Prior Sarah Prior true false c6cd8267ff0b13f2ea333bbfefdae144 Rachel Churm Rachel Churm true false c6cd8267ff0b13f2ea333bbfefdae144 Rachel Churm Rachel Churm true false c6cd8267ff0b13f2ea333bbfefdae144 Rachel Churm Rachel Churm true false c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false 2019-06-06 PMSC Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter gene variant, which encodes COX-2, in relation to markers of cardiovascular risk in a sample of well-characterised subjects with diabetes mellitus. Methods & Results: We observed that the CC genotype was more prevalent in Type 2 diabetes mellitus compared to Type 1 (84.2 vs 15.8%; p≤0.05), and was significantly associated with clinically manifest angina (GG vs GC vs CC: 14.3% vs 15.6% vs 28.0%; p=0.009) and lower HDL-cholesterol levels (GG vs GC vs CC: 1.3mmol/L vs 1.4mmol/L vs 1.2mmol/L; p=0.032). This is in line with previous studies showing that -765G>C genotype variant alters Sp1 binding, resulting in decreased COX-2 activity which is associated with atherosclerosis. Conclusion: We conclude that the CC genotype may contribute to a reduction of prostaglandin E2 mediated insulin secretion, predisposing those individuals to Type 2 diabetes mellitus. Further prospective work is warranted in order to examine the association between COX-2 and cardiovascular risk. Journal Article Journal of Diabetes & Metabolism 7 7 21556156 COX-2; polymorphism; Type 2 diabetes; HDL; angina; cardiovascular 1 1 2016 2016-01-01 10.4172/2155-6156.1000686 COLLEGE NANME Medicine COLLEGE CODE PMSC Swansea University 2019-06-18T08:52:51.6958150 2019-06-06T09:57:30.9921084 Swansea University Medical School Medicine Rachel Churm 0000-0001-9855-6282 1 T Oliver 2 SJ Hurel 3 SE Humphries 4 JW Stephens 5 SL Prior 6 Sarah Prior 0000-0001-8703-8092 7 0050671-18062019085029.pdf 50671.pdf 2019-06-18T08:50:29.8530000 Output 325608 application/pdf Version of Record true 2019-06-17T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
spellingShingle The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
Sarah, Prior
Rachel, Churm
Rachel, Churm
Rachel, Churm
Rachel, Churm
title_short The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_full The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_fullStr The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_full_unstemmed The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
title_sort The -765G>C Cyclooxygenase-2 Promoter Polymorphism is associated with Type 2 Diabetes Mellitus, Low High-density Lipoprotein and Manifest Angina
author_id_str_mv cdda101035997acfaa6fdf17097f52b2
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c6cd8267ff0b13f2ea333bbfefdae144
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author_id_fullname_str_mv cdda101035997acfaa6fdf17097f52b2_***_Sarah, Prior
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel, Churm
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel, Churm
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel, Churm
c6cd8267ff0b13f2ea333bbfefdae144_***_Rachel, Churm
author Sarah, Prior
Rachel, Churm
Rachel, Churm
Rachel, Churm
Rachel, Churm
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publishDate 2016
institution Swansea University
issn 21556156
doi_str_mv 10.4172/2155-6156.1000686
college_str Swansea University Medical School
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hierarchy_top_title Swansea University Medical School
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description Background & Aims: Cycloxygenase-2 (COX-2) catalyses the rate limiting step of prostaglandin biosynthesis. Despite previous studies, it is still unclear whether COX-2 is beneficial or detrimental to cardiovascular risk. The aim of this study was to examine the -765G>C (rs20417) PTGS2 promoter gene variant, which encodes COX-2, in relation to markers of cardiovascular risk in a sample of well-characterised subjects with diabetes mellitus. Methods & Results: We observed that the CC genotype was more prevalent in Type 2 diabetes mellitus compared to Type 1 (84.2 vs 15.8%; p≤0.05), and was significantly associated with clinically manifest angina (GG vs GC vs CC: 14.3% vs 15.6% vs 28.0%; p=0.009) and lower HDL-cholesterol levels (GG vs GC vs CC: 1.3mmol/L vs 1.4mmol/L vs 1.2mmol/L; p=0.032). This is in line with previous studies showing that -765G>C genotype variant alters Sp1 binding, resulting in decreased COX-2 activity which is associated with atherosclerosis. Conclusion: We conclude that the CC genotype may contribute to a reduction of prostaglandin E2 mediated insulin secretion, predisposing those individuals to Type 2 diabetes mellitus. Further prospective work is warranted in order to examine the association between COX-2 and cardiovascular risk.
published_date 2016-01-01T19:22:27Z
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