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Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
,
Stefano Perni,
Polina Prokopovich
Nanomedicine: Nanotechnology, Biology and Medicine, Volume: 12, Issue: 3, Pages: 723 - 734
Swansea University Author:
Emily Preedy
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DOI (Published version): 10.1016/j.nano.2015.10.006
Abstract
Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic a...
| Published in: | Nanomedicine: Nanotechnology, Biology and Medicine |
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| ISSN: | 1549-9634 |
| Published: |
Elsevier BV
2016
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa51207 |
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| Abstract: |
Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre- and post-CAP treatment. The results indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 h of contact and the particle concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; while with longer CAP treatment this was not observed. |
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| Keywords: |
rMSC, UHMWPE, Wear debris, AFM, Cold gas plasma |
| College: |
Faculty of Science and Engineering |
| Issue: |
3 |
| Start Page: |
723 |
| End Page: |
734 |