No Cover Image

Journal article 125 views 69 downloads

Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles

Emily Preedy Orcid Logo, Stefano Perni, Polina Prokopovich

Nanomedicine: Nanotechnology, Biology and Medicine, Volume: 12, Issue: 3, Pages: 723 - 734

Swansea University Author: Emily Preedy Orcid Logo

  • preedy2015.pdf

    PDF | Version of Record

    Released under the terms of a Creative Commons Attribution License (CC-BY).

    Download (2.8MB)

Check full text

DOI (Published version): 10.1016/j.nano.2015.10.006

Abstract

Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic a...

Full description

Published in: Nanomedicine: Nanotechnology, Biology and Medicine
ISSN: 1549-9634
Published: Elsevier BV 2016
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa51207
Tags: Add Tag
No Tags, Be the first to tag this record!
first_indexed 2019-07-25T17:48:23Z
last_indexed 2020-10-20T03:01:47Z
id cronfa51207
recordtype SURis
fullrecord <?xml version="1.0"?><rfc1807><datestamp>2020-10-19T14:31:46.4278964</datestamp><bib-version>v2</bib-version><id>51207</id><entry>2019-07-25</entry><title>Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles</title><swanseaauthors><author><sid>a4ae2d29d6b017b303c85efa3a9503d0</sid><ORCID>0000-0003-0377-6747</ORCID><firstname>Emily</firstname><surname>Preedy</surname><name>Emily Preedy</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-07-25</date><deptcode>CHEG</deptcode><abstract>Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre- and post-CAP treatment. The results indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 h of contact and the particle concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; while with longer CAP treatment this was not observed.</abstract><type>Journal Article</type><journal>Nanomedicine: Nanotechnology, Biology and Medicine</journal><volume>12</volume><journalNumber>3</journalNumber><paginationStart>723</paginationStart><paginationEnd>734</paginationEnd><publisher>Elsevier BV</publisher><issnPrint>1549-9634</issnPrint><keywords>rMSC, UHMWPE, Wear debris, AFM, Cold gas plasma</keywords><publishedDay>1</publishedDay><publishedMonth>4</publishedMonth><publishedYear>2016</publishedYear><publishedDate>2016-04-01</publishedDate><doi>10.1016/j.nano.2015.10.006</doi><url/><notes/><college>COLLEGE NANME</college><department>Chemical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>CHEG</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2020-10-19T14:31:46.4278964</lastEdited><Created>2019-07-25T14:14:40.6555760</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Chemical Engineering</level></path><authors><author><firstname>Emily</firstname><surname>Preedy</surname><orcid>0000-0003-0377-6747</orcid><order>1</order></author><author><firstname>Stefano</firstname><surname>Perni</surname><order>2</order></author><author><firstname>Polina</firstname><surname>Prokopovich</surname><order>3</order></author></authors><documents><document><filename>0051207-07082019123719.pdf</filename><originalFilename>preedy2015.pdf</originalFilename><uploaded>2019-08-07T12:37:19.0430000</uploaded><type>Output</type><contentLength>3010373</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-08-07T00:00:00.0000000</embargoDate><documentNotes>Released under the terms of a Creative Commons Attribution License (CC-BY).</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807>
spelling 2020-10-19T14:31:46.4278964 v2 51207 2019-07-25 Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles a4ae2d29d6b017b303c85efa3a9503d0 0000-0003-0377-6747 Emily Preedy Emily Preedy true false 2019-07-25 CHEG Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre- and post-CAP treatment. The results indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 h of contact and the particle concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; while with longer CAP treatment this was not observed. Journal Article Nanomedicine: Nanotechnology, Biology and Medicine 12 3 723 734 Elsevier BV 1549-9634 rMSC, UHMWPE, Wear debris, AFM, Cold gas plasma 1 4 2016 2016-04-01 10.1016/j.nano.2015.10.006 COLLEGE NANME Chemical Engineering COLLEGE CODE CHEG Swansea University 2020-10-19T14:31:46.4278964 2019-07-25T14:14:40.6555760 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Emily Preedy 0000-0003-0377-6747 1 Stefano Perni 2 Polina Prokopovich 3 0051207-07082019123719.pdf preedy2015.pdf 2019-08-07T12:37:19.0430000 Output 3010373 application/pdf Version of Record true 2019-08-07T00:00:00.0000000 Released under the terms of a Creative Commons Attribution License (CC-BY). true eng
title Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
spellingShingle Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
Emily Preedy
title_short Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
title_full Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
title_fullStr Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
title_full_unstemmed Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
title_sort Nanomechanical and surface properties of rMSCs post-exposure to CAP treated UHMWPE wear particles
author_id_str_mv a4ae2d29d6b017b303c85efa3a9503d0
author_id_fullname_str_mv a4ae2d29d6b017b303c85efa3a9503d0_***_Emily Preedy
author Emily Preedy
author2 Emily Preedy
Stefano Perni
Polina Prokopovich
format Journal article
container_title Nanomedicine: Nanotechnology, Biology and Medicine
container_volume 12
container_issue 3
container_start_page 723
publishDate 2016
institution Swansea University
issn 1549-9634
doi_str_mv 10.1016/j.nano.2015.10.006
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Wear debris generated by ultra-high molecular weight polyethylene (UHMWPE) used in joint replacement devices has been of concern due to reductions of the implant longevity. Cold atmospheric plasma (CAP) has been used to improve the wear performance of UHMWPE. Our aim was to investigate the elastic and adhesive properties of rat mesenchymal stem cells (rMSCs), through AFM, after exposure to UHMWPE wear debris pre- and post-CAP treatment. The results indicated that the main changes in cell elasticity and spring constant of MSC exposed to wear particles occurred in the first 24 h of contact and the particle concentration from 0.5 to 50 mg/l did not play a significant role. For UHMWPE treated for 7.5 min, with progression of the wear simulation the results of the CAP treated samples were getting closer to the result of untreated samples; while with longer CAP treatment this was not observed.
published_date 2016-04-01T04:03:00Z
_version_ 1763753256198078464
score 10.999207

Similar Items