Journal article 825 views 86 downloads
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence
Jon Brazier,
Mark Antrobus,
Georgina Stebbings,
Stephen Day,
Shane Heffernan
,
Matthew Cross,
Alun Williams
Sports, Volume: 7, Issue: 6, Start page: 138
Swansea University Author:
Shane Heffernan
-
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DOI (Published version): 10.3390/sports7060138
Abstract
This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest rep...
Published in: | Sports |
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ISSN: | 2075-4663 |
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2019
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URI: | https://cronfa.swan.ac.uk/Record/cronfa51434 |
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<?xml version="1.0"?><rfc1807><datestamp>2019-09-02T16:06:46.9860666</datestamp><bib-version>v2</bib-version><id>51434</id><entry>2019-08-16</entry><title>Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence</title><swanseaauthors><author><sid>72c0b36891dfbec0378c0d0f7916e807</sid><ORCID>0000-0002-3297-9335</ORCID><firstname>Shane</firstname><surname>Heffernan</surname><name>Shane Heffernan</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-08-16</date><deptcode>STSC</deptcode><abstract>This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports.</abstract><type>Journal Article</type><journal>Sports</journal><volume>7</volume><journalNumber>6</journalNumber><paginationStart>138</paginationStart><publisher/><issnElectronic>2075-4663</issnElectronic><keywords>genomics; rugby; polymorphisms; soft-tissue injury; tendinopathy; ligament rupture</keywords><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-12-31</publishedDate><doi>10.3390/sports7060138</doi><url/><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-09-02T16:06:46.9860666</lastEdited><Created>2019-08-16T10:48:48.2462397</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Jon</firstname><surname>Brazier</surname><order>1</order></author><author><firstname>Mark</firstname><surname>Antrobus</surname><order>2</order></author><author><firstname>Georgina</firstname><surname>Stebbings</surname><order>3</order></author><author><firstname>Stephen</firstname><surname>Day</surname><order>4</order></author><author><firstname>Shane</firstname><surname>Heffernan</surname><orcid>0000-0002-3297-9335</orcid><order>5</order></author><author><firstname>Matthew</firstname><surname>Cross</surname><order>6</order></author><author><firstname>Alun</firstname><surname>Williams</surname><order>7</order></author></authors><documents><document><filename>0051434-02092019160611.pdf</filename><originalFilename>brazier2019.pdf</originalFilename><uploaded>2019-09-02T16:06:11.7570000</uploaded><type>Output</type><contentLength>870230</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><embargoDate>2019-09-02T00:00:00.0000000</embargoDate><copyrightCorrect>false</copyrightCorrect><language>eng</language></document></documents><OutputDurs/></rfc1807> |
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2019-09-02T16:06:46.9860666 v2 51434 2019-08-16 Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2019-08-16 STSC This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports. Journal Article Sports 7 6 138 2075-4663 genomics; rugby; polymorphisms; soft-tissue injury; tendinopathy; ligament rupture 31 12 2019 2019-12-31 10.3390/sports7060138 COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2019-09-02T16:06:46.9860666 2019-08-16T10:48:48.2462397 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Jon Brazier 1 Mark Antrobus 2 Georgina Stebbings 3 Stephen Day 4 Shane Heffernan 0000-0002-3297-9335 5 Matthew Cross 6 Alun Williams 7 0051434-02092019160611.pdf brazier2019.pdf 2019-09-02T16:06:11.7570000 Output 870230 application/pdf Version of Record true 2019-09-02T00:00:00.0000000 false eng |
title |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
spellingShingle |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence Shane Heffernan |
title_short |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
title_full |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
title_fullStr |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
title_full_unstemmed |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
title_sort |
Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence |
author_id_str_mv |
72c0b36891dfbec0378c0d0f7916e807 |
author_id_fullname_str_mv |
72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan |
author |
Shane Heffernan |
author2 |
Jon Brazier Mark Antrobus Georgina Stebbings Stephen Day Shane Heffernan Matthew Cross Alun Williams |
format |
Journal article |
container_title |
Sports |
container_volume |
7 |
container_issue |
6 |
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138 |
publishDate |
2019 |
institution |
Swansea University |
issn |
2075-4663 |
doi_str_mv |
10.3390/sports7060138 |
college_str |
Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
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facultyofscienceandengineering |
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Faculty of Science and Engineering |
department_str |
School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences |
document_store_str |
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description |
This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone), and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and COLGALT1 warrant further study within elite rugby and other invasion sports. |
published_date |
2019-12-31T04:03:18Z |
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1763753275031552000 |
score |
11.021648 |