Journal article 730 views
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
Micro & Nano Letters, Volume: 14, Issue: 5, Pages: 511 - 514
Swansea University Author: Feihu Zhao
Full text not available from this repository: check for access using links below.
DOI (Published version): 10.1049/mnl.2018.5458
Abstract
The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effect...
Published in: | Micro & Nano Letters |
---|---|
ISSN: | 1750-0443 |
Published: |
2019
|
Online Access: |
Check full text
|
URI: | https://cronfa.swan.ac.uk/Record/cronfa51680 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
first_indexed |
2019-09-04T20:46:37Z |
---|---|
last_indexed |
2019-10-11T14:23:30Z |
id |
cronfa51680 |
recordtype |
SURis |
fullrecord |
<?xml version="1.0"?><rfc1807><datestamp>2019-10-11T10:17:08.1975341</datestamp><bib-version>v2</bib-version><id>51680</id><entry>2019-09-04</entry><title>Cardiomyocyte contractile force changes in response to AGRWE detected by AFM</title><swanseaauthors><author><sid>1c6e79b6edd08c88a8d17a241cd78630</sid><ORCID>0000-0003-0515-6808</ORCID><firstname>Feihu</firstname><surname>Zhao</surname><name>Feihu Zhao</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-09-04</date><deptcode>MEDE</deptcode><abstract>The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.</abstract><type>Journal Article</type><journal>Micro & Nano Letters</journal><volume>14</volume><journalNumber>5</journalNumber><paginationStart>511</paginationStart><paginationEnd>514</paginationEnd><publisher/><issnElectronic>1750-0443</issnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-12-31</publishedDate><doi>10.1049/mnl.2018.5458</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-10-11T10:17:08.1975341</lastEdited><Created>2019-09-04T15:40:44.4598717</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>YingMin</firstname><surname>Qu</surname><order>1</order></author><author><firstname>Feihu</firstname><surname>Zhao</surname><orcid>0000-0003-0515-6808</orcid><order>2</order></author><author><firstname>Xinyue</firstname><surname>Wang</surname><order>3</order></author><author><firstname>Jinyun</firstname><surname>Liu</surname><order>4</order></author><author><firstname>Jingmei</firstname><surname>Li</surname><order>5</order></author><author><firstname>Zhengxun</firstname><surname>Song</surname><order>6</order></author><author><firstname>Zuobin</firstname><surname>Wang</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807> |
spelling |
2019-10-11T10:17:08.1975341 v2 51680 2019-09-04 Cardiomyocyte contractile force changes in response to AGRWE detected by AFM 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 MEDE The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure. Journal Article Micro & Nano Letters 14 5 511 514 1750-0443 31 12 2019 2019-12-31 10.1049/mnl.2018.5458 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2019-10-11T10:17:08.1975341 2019-09-04T15:40:44.4598717 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering YingMin Qu 1 Feihu Zhao 0000-0003-0515-6808 2 Xinyue Wang 3 Jinyun Liu 4 Jingmei Li 5 Zhengxun Song 6 Zuobin Wang 7 |
title |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
spellingShingle |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM Feihu Zhao |
title_short |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
title_full |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
title_fullStr |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
title_full_unstemmed |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
title_sort |
Cardiomyocyte contractile force changes in response to AGRWE detected by AFM |
author_id_str_mv |
1c6e79b6edd08c88a8d17a241cd78630 |
author_id_fullname_str_mv |
1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao |
author |
Feihu Zhao |
author2 |
YingMin Qu Feihu Zhao Xinyue Wang Jinyun Liu Jingmei Li Zhengxun Song Zuobin Wang |
format |
Journal article |
container_title |
Micro & Nano Letters |
container_volume |
14 |
container_issue |
5 |
container_start_page |
511 |
publishDate |
2019 |
institution |
Swansea University |
issn |
1750-0443 |
doi_str_mv |
10.1049/mnl.2018.5458 |
college_str |
Faculty of Science and Engineering |
hierarchytype |
|
hierarchy_top_id |
facultyofscienceandengineering |
hierarchy_top_title |
Faculty of Science and Engineering |
hierarchy_parent_id |
facultyofscienceandengineering |
hierarchy_parent_title |
Faculty of Science and Engineering |
department_str |
School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering |
document_store_str |
0 |
active_str |
0 |
description |
The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure. |
published_date |
2019-12-31T04:03:40Z |
_version_ |
1763753297579081728 |
score |
11.0267 |