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Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

YingMin Qu, Feihu Zhao Orcid Logo, Xinyue Wang, Jinyun Liu, Jingmei Li, Zhengxun Song, Zuobin Wang

Micro & Nano Letters, Volume: 14, Issue: 5, Pages: 511 - 514

Swansea University Author: Feihu Zhao Orcid Logo

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DOI (Published version): 10.1049/mnl.2018.5458

Abstract

The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effect...

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Published in: Micro & Nano Letters
ISSN: 1750-0443
Published: 2019
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URI: https://cronfa.swan.ac.uk/Record/cronfa51680
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first_indexed 2019-09-04T20:46:37Z
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2019-10-11T10:17:08.1975341</datestamp><bib-version>v2</bib-version><id>51680</id><entry>2019-09-04</entry><title>Cardiomyocyte contractile force changes in response to AGRWE detected by AFM</title><swanseaauthors><author><sid>1c6e79b6edd08c88a8d17a241cd78630</sid><ORCID>0000-0003-0515-6808</ORCID><firstname>Feihu</firstname><surname>Zhao</surname><name>Feihu Zhao</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2019-09-04</date><deptcode>MEDE</deptcode><abstract>The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 &#x3BC;g/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 &#xB1; 1.01 to 3.49 &#xB1; 1.53 nN. The mean value of the contractile strain calculated was 3.32 &#xB1; 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 &#xB1; 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 &#xB1; 11 beats/min (control, n = 10) to 20 &#xB1; 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.</abstract><type>Journal Article</type><journal>Micro &amp; Nano Letters</journal><volume>14</volume><journalNumber>5</journalNumber><paginationStart>511</paginationStart><paginationEnd>514</paginationEnd><publisher/><issnElectronic>1750-0443</issnElectronic><keywords/><publishedDay>31</publishedDay><publishedMonth>12</publishedMonth><publishedYear>2019</publishedYear><publishedDate>2019-12-31</publishedDate><doi>10.1049/mnl.2018.5458</doi><url/><notes/><college>COLLEGE NANME</college><department>Biomedical Engineering</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>MEDE</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2019-10-11T10:17:08.1975341</lastEdited><Created>2019-09-04T15:40:44.4598717</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Engineering and Applied Sciences - Biomedical Engineering</level></path><authors><author><firstname>YingMin</firstname><surname>Qu</surname><order>1</order></author><author><firstname>Feihu</firstname><surname>Zhao</surname><orcid>0000-0003-0515-6808</orcid><order>2</order></author><author><firstname>Xinyue</firstname><surname>Wang</surname><order>3</order></author><author><firstname>Jinyun</firstname><surname>Liu</surname><order>4</order></author><author><firstname>Jingmei</firstname><surname>Li</surname><order>5</order></author><author><firstname>Zhengxun</firstname><surname>Song</surname><order>6</order></author><author><firstname>Zuobin</firstname><surname>Wang</surname><order>7</order></author></authors><documents/><OutputDurs/></rfc1807>
spelling 2019-10-11T10:17:08.1975341 v2 51680 2019-09-04 Cardiomyocyte contractile force changes in response to AGRWE detected by AFM 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2019-09-04 MEDE The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure. Journal Article Micro & Nano Letters 14 5 511 514 1750-0443 31 12 2019 2019-12-31 10.1049/mnl.2018.5458 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University 2019-10-11T10:17:08.1975341 2019-09-04T15:40:44.4598717 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering YingMin Qu 1 Feihu Zhao 0000-0003-0515-6808 2 Xinyue Wang 3 Jinyun Liu 4 Jingmei Li 5 Zhengxun Song 6 Zuobin Wang 7
title Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
spellingShingle Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
Feihu Zhao
title_short Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
title_full Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
title_fullStr Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
title_full_unstemmed Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
title_sort Cardiomyocyte contractile force changes in response to AGRWE detected by AFM
author_id_str_mv 1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Feihu Zhao
author2 YingMin Qu
Feihu Zhao
Xinyue Wang
Jinyun Liu
Jingmei Li
Zhengxun Song
Zuobin Wang
format Journal article
container_title Micro & Nano Letters
container_volume 14
container_issue 5
container_start_page 511
publishDate 2019
institution Swansea University
issn 1750-0443
doi_str_mv 10.1049/mnl.2018.5458
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
document_store_str 0
active_str 0
description The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes' contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.
published_date 2019-12-31T04:03:40Z
_version_ 1763753297579081728
score 11.012678

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