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Conference Paper/Proceeding/Abstract 376 views

The Challenges in developing a Faecal Transplantation Bank for the Treatment of IBD

Matthew Hitchings Orcid Logo, Andrew Cunningham, Sue Chandler, Dean Harris Orcid Logo

Falk Foundation Symposium 217: West Meets East: Functional Meets Organic in Gastrointestinal Diseases

Swansea University Authors: Matthew Hitchings Orcid Logo, Dean Harris Orcid Logo

Abstract

Faecal Microbiota Transplantation (FMT) was first recorded over 2000 years ago for the treatment of severe diarrhoea. FMT is an infusion of a faecal suspension from a healthy individual to the GI tract of a recipient patient, in order to treat a disorder associated with an alteration of gut microbio...

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Published in: Falk Foundation Symposium 217: West Meets East: Functional Meets Organic in Gastrointestinal Diseases
Published: 2019
Online Access: http://www.falk-foundation-symposia.org/symposia-and-workshops/2019/?L=1
URI: https://cronfa.swan.ac.uk/Record/cronfa53364
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Abstract: Faecal Microbiota Transplantation (FMT) was first recorded over 2000 years ago for the treatment of severe diarrhoea. FMT is an infusion of a faecal suspension from a healthy individual to the GI tract of a recipient patient, in order to treat a disorder associated with an alteration of gut microbiota. It is proposed that Ulcerative Colitis (UC) is caused by a bacteria or group of bacteria within the microbiome interacting with genetically susceptible individuals to cause chronic relapsing inflammation of the colon. Increasing evidence has shown frozen faecal infusions from unrelated donors are as effective as related donors which has provided an opportunity for a better standardised approach for donor selection, screening, and treatment preparation.