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Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics / Benoit Toubhans, Salvatore Gazze, Caroline Bissardon, Sylvain Bohic, Alexandra T. Gourlan, Deya Gonzalez, Laurent Charlet, Steve Conlan, Lewis Francis

Nanomedicine: Nanotechnology, Biology and Medicine, Volume: 29, Start page: 102258

Swansea University Authors: Salvatore Gazze, Deya Gonzalez, Steve Conlan, Lewis Francis

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Abstract

High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we e...

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Published in: Nanomedicine: Nanotechnology, Biology and Medicine
ISSN: 1549-9634
Published: Elsevier BV 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa54635
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Abstract: High dose selenium acts as a cytotoxic agent, with potential applications in cancer treatment. However, clinical trials have failed to show any chemotherapeutic value of selenium at safe and tolerated doses (<90 μg/day). To enable the successful exploitation of selenium for cancer treatment, we evaluated inorganic selenium nanoparticles (SeNP), and found them effective in inhibiting ovarian cancer cell growth. In both SKOV-3 and OVCAR-3 ovarian cancer cell types SeNP treatment resulted in significant cytotoxicity. The two cell types displayed contrasting nanomechanical responses to SeNPs, with decreased surface roughness and membrane stiffness, characteristics of OVCAR-3 cell death. In SKOV-3, cell membrane surface roughness and stiffness increased, both properties associated with decreased metastatic potential. The beneficial effects of SeNPs on ovarian cancer cell death appear cell type dependent, and due to their low in vivo toxicity offer an exciting opportunity for future cancer treatment.
Keywords: Selenium; Nanoparticles; Nanomechanics; Ovarian Cancer; Metastasis
College: Swansea University Medical School
Start Page: 102258