Journal article 648 views 310 downloads
Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
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Yufei Liu
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume: 243, Start page: 118804
Swansea University Author:
Lijie Li
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DOI (Published version): 10.1016/j.saa.2020.118804
Abstract
The detection of Dopamine (DA) is significant for disease surveillance and prevention. However, the development of the precise and simple detection techniques is still at a preliminary stage due to their high tester requirements, time-consuming process, and low accuracy. In this work, we present a n...
| Published in: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy |
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| ISSN: | 1386-1425 |
| Published: |
Elsevier BV
2020
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa54928 |
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| Abstract: |
The detection of Dopamine (DA) is significant for disease surveillance and prevention. However, the development of the precise and simple detection techniques is still at a preliminary stage due to their high tester requirements, time-consuming process, and low accuracy. In this work, we present a novel dual-emission ratiometric fluorescence sensing system based on a hybrid of carbon dots (CDs) and 7-amino-4-methylcoumarin (AMC) to quickly monitor the DA concentration. Linked via amide bonds, the CDs and AMC offered dual-emissions with peaks located at 455 and 505 nm, respectively, under a single excitation wavelength of 300 nm. Attributed to the fluorescence of the CDs and AMC in the nanohybrid system can be quenched by DA, the concentration of DA could be quantitatively detected by monitoring the ratiometric ratio change in fluorescent intensity. More importantly, the CDs-AMC-based dual-emission ratiometric fluorescence sensing system demonstrated a remarkable linear relationship in the range of 0–33.6 μM to detection of DA, and a low detection limit of 5.67 nM. Additionally, this sensor successfully applied to the detection of DA in real samples. Therefore, the ratiometric fluorescence sensing system may become promising to find potential applications in biomedical dopamine detection. |
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| Keywords: |
Ratiometric fluorescence, Carbon dots, Dopamine, Biosensor |
| College: |
Faculty of Science and Engineering |
| Start Page: |
118804 |