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Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection

Jia An, Meizhu Chen, Nan Hu, Yongqin Hu, Rubing Chen, Ying Lyu, Wenxi Guo, Lijie Li Orcid Logo, Yufei Liu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume: 243, Start page: 118804

Swansea University Author: Lijie Li Orcid Logo

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DOI (Published version): 10.1016/j.saa.2020.118804

Abstract

The detection of Dopamine (DA) is significant for disease surveillance and prevention. However, the development of the precise and simple detection techniques is still at a preliminary stage due to their high tester requirements, time-consuming process, and low accuracy. In this work, we present a n...

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Published in: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN: 1386-1425
Published: Elsevier BV 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa54928
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spelling 2020-09-21T11:10:07.3626035 v2 54928 2020-08-10 Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection ed2c658b77679a28e4c1dcf95af06bd6 0000-0003-4630-7692 Lijie Li Lijie Li true false 2020-08-10 EEEG The detection of Dopamine (DA) is significant for disease surveillance and prevention. However, the development of the precise and simple detection techniques is still at a preliminary stage due to their high tester requirements, time-consuming process, and low accuracy. In this work, we present a novel dual-emission ratiometric fluorescence sensing system based on a hybrid of carbon dots (CDs) and 7-amino-4-methylcoumarin (AMC) to quickly monitor the DA concentration. Linked via amide bonds, the CDs and AMC offered dual-emissions with peaks located at 455 and 505 nm, respectively, under a single excitation wavelength of 300 nm. Attributed to the fluorescence of the CDs and AMC in the nanohybrid system can be quenched by DA, the concentration of DA could be quantitatively detected by monitoring the ratiometric ratio change in fluorescent intensity. More importantly, the CDs-AMC-based dual-emission ratiometric fluorescence sensing system demonstrated a remarkable linear relationship in the range of 0–33.6 μM to detection of DA, and a low detection limit of 5.67 nM. Additionally, this sensor successfully applied to the detection of DA in real samples. Therefore, the ratiometric fluorescence sensing system may become promising to find potential applications in biomedical dopamine detection. Journal Article Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 243 118804 Elsevier BV 1386-1425 Ratiometric fluorescence, Carbon dots, Dopamine, Biosensor 15 12 2020 2020-12-15 10.1016/j.saa.2020.118804 COLLEGE NANME Electronic and Electrical Engineering COLLEGE CODE EEEG Swansea University 2020-09-21T11:10:07.3626035 2020-08-10T18:49:18.3301071 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering Jia An 1 Meizhu Chen 2 Nan Hu 3 Yongqin Hu 4 Rubing Chen 5 Ying Lyu 6 Wenxi Guo 7 Lijie Li 0000-0003-4630-7692 8 Yufei Liu 9 54928__17889__d9149b6358dd4d6fa8a39c6d01d0e592.pdf SSA_accepted.pdf 2020-08-10T18:50:26.6754092 Output 945708 application/pdf Accepted Manuscript true 2021-08-10T00:00:00.0000000 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ true English
title Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
spellingShingle Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
Lijie Li
title_short Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
title_full Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
title_fullStr Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
title_full_unstemmed Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
title_sort Carbon dots-based dual-emission ratiometric fluorescence sensor for dopamine detection
author_id_str_mv ed2c658b77679a28e4c1dcf95af06bd6
author_id_fullname_str_mv ed2c658b77679a28e4c1dcf95af06bd6_***_Lijie Li
author Lijie Li
author2 Jia An
Meizhu Chen
Nan Hu
Yongqin Hu
Rubing Chen
Ying Lyu
Wenxi Guo
Lijie Li
Yufei Liu
format Journal article
container_title Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
container_volume 243
container_start_page 118804
publishDate 2020
institution Swansea University
issn 1386-1425
doi_str_mv 10.1016/j.saa.2020.118804
publisher Elsevier BV
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Electronic and Electrical Engineering
document_store_str 1
active_str 0
description The detection of Dopamine (DA) is significant for disease surveillance and prevention. However, the development of the precise and simple detection techniques is still at a preliminary stage due to their high tester requirements, time-consuming process, and low accuracy. In this work, we present a novel dual-emission ratiometric fluorescence sensing system based on a hybrid of carbon dots (CDs) and 7-amino-4-methylcoumarin (AMC) to quickly monitor the DA concentration. Linked via amide bonds, the CDs and AMC offered dual-emissions with peaks located at 455 and 505 nm, respectively, under a single excitation wavelength of 300 nm. Attributed to the fluorescence of the CDs and AMC in the nanohybrid system can be quenched by DA, the concentration of DA could be quantitatively detected by monitoring the ratiometric ratio change in fluorescent intensity. More importantly, the CDs-AMC-based dual-emission ratiometric fluorescence sensing system demonstrated a remarkable linear relationship in the range of 0–33.6 μM to detection of DA, and a low detection limit of 5.67 nM. Additionally, this sensor successfully applied to the detection of DA in real samples. Therefore, the ratiometric fluorescence sensing system may become promising to find potential applications in biomedical dopamine detection.
published_date 2020-12-15T04:08:46Z
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score 11.035634

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