Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

Oliva, Paola; Romagnoli, Romeo; Manfredini, Stefano; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Ronca, Roberto; Maccarinelli, Federica; Giacomini, Arianna; Rruga, Fatlum; Mariotto, Elena; Viola, Giampietro; Bortolozzi, Roberta

doi:10.1016/j.ejmech.2020.112448

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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

Paola Oliva, Romeo Romagnoli, Stefano Manfredini, Andrea Brancale, Salvatore Ferla

, Ernest Hamel, Roberto Ronca, Federica Maccarinelli, Arianna Giacomini, Fatlum Rruga, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi

European Journal of Medicinal Chemistry, Volume: 200, Start page: 112448

Swansea University Author: Salvatore Ferla

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DOI (Published version): 10.1016/j.ejmech.2020.112448

Published in:	European Journal of Medicinal Chemistry
ISSN:	0223-5234
Published:	Elsevier BV 2020
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa55226
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first_indexed	2020-10-18T17:15:32Z
last_indexed	2020-11-25T04:12:01Z
id	cronfa55226
recordtype	SURis
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spelling	2020-11-24T17:09:26.3858158 v2 55226 2020-09-20 Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors d4c62248f510e3b221916989a7bbe6a6 0000-0002-5918-9237 Salvatore Ferla Salvatore Ferla true false 2020-09-20 PHAR Journal Article European Journal of Medicinal Chemistry 200 112448 Elsevier BV 0223-5234 Microtubules; Benzo[b]furan; In vivo activity; Inhibition tubulin assembly; Colchicine binding site 15 8 2020 2020-08-15 10.1016/j.ejmech.2020.112448 http://orca.cf.ac.uk/131812/ COLLEGE NANME Pharmacy COLLEGE CODE PHAR Swansea University 2020-11-24T17:09:26.3858158 2020-09-20T14:09:06.9904500 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Paola Oliva 1 Romeo Romagnoli 2 Stefano Manfredini 3 Andrea Brancale 4 Salvatore Ferla 0000-0002-5918-9237 5 Ernest Hamel 6 Roberto Ronca 7 Federica Maccarinelli 8 Arianna Giacomini 9 Fatlum Rruga 10 Elena Mariotto 11 Giampietro Viola 12 Roberta Bortolozzi 13
title	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
spellingShingle	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors Salvatore Ferla
title_short	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
title_full	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
title_fullStr	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
title_full_unstemmed	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
title_sort	Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors
author_id_str_mv	d4c62248f510e3b221916989a7bbe6a6
author_id_fullname_str_mv	d4c62248f510e3b221916989a7bbe6a6_***_Salvatore Ferla
author	Salvatore Ferla
author2	Paola Oliva Romeo Romagnoli Stefano Manfredini Andrea Brancale Salvatore Ferla Ernest Hamel Roberto Ronca Federica Maccarinelli Arianna Giacomini Fatlum Rruga Elena Mariotto Giampietro Viola Roberta Bortolozzi
format	Journal article
container_title	European Journal of Medicinal Chemistry
container_volume	200
container_start_page	112448
publishDate	2020
institution	Swansea University
issn	0223-5234
doi_str_mv	10.1016/j.ejmech.2020.112448
publisher	Elsevier BV
college_str	Faculty of Medicine, Health and Life Sciences
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hierarchy_top_id	facultyofmedicinehealthandlifesciences
hierarchy_top_title	Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id	facultyofmedicinehealthandlifesciences
hierarchy_parent_title	Faculty of Medicine, Health and Life Sciences
department_str	Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
url	http://orca.cf.ac.uk/131812/
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published_date	2020-08-15T04:09:18Z
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Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors

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