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On the poro-elastic models for microvascular blood flow resistance: An in vitro validation / Alberto Coccarelli, Supratim Saha, Tanjeri Purushotham, K. Arul Prakash, Perumal Nithiarasu

Journal of Biomechanics, Volume: 117, Start page: 110241

Swansea University Authors: Alberto Coccarelli, Perumal Nithiarasu

  • Accepted Manuscript under embargo until: 13th January 2022

Abstract

Nowadays, adequate and accurate representation of the microvascular flow resistance constitutes one of the major challenges in computational haemodynamic studies. In this work, a theoretical, porous media framework, ultimately designed for representing downstream resistance, is presented and compare...

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Published in: Journal of Biomechanics
ISSN: 0021-9290
Published: Elsevier BV 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa56004
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spelling 2021-02-01T17:22:17.2479181 v2 56004 2021-01-11 On the poro-elastic models for microvascular blood flow resistance: An in vitro validation 06fd3332e5eb3cf4bb4e75a24f49149d 0000-0003-1511-9015 Alberto Coccarelli Alberto Coccarelli true false 3b28bf59358fc2b9bd9a46897dbfc92d 0000-0002-4901-2980 Perumal Nithiarasu Perumal Nithiarasu true false 2021-01-11 MECH Nowadays, adequate and accurate representation of the microvascular flow resistance constitutes one of the major challenges in computational haemodynamic studies. In this work, a theoretical, porous media framework, ultimately designed for representing downstream resistance, is presented and compared against an in vitro experimental results. The resistor consists of a poro-elastic tube, with either a constant or variable porosity profile in space. The underlying physics, characterizing the fluid flow through the porous media, is analysed by considering flow variables at different network locations. Backward reflections, originated in the reservoir of the in vitro model, are accounted for through a reflection coefficient imposed as an outflow network condition. The simulation results are in good agreement with the measurements for both the homogenous and heterogeneous porosity conditions. In addition, the comparison allows identification of the range of values representing experimental reservoir reflection coefficients. The pressure drops across the heterogeneous porous media increases with respect to the simpler configuration, whilst flow remains almost unchanged. The effect of some fluid network features, such as tube Young’s modulus and fluid viscosity, on the theoretical results is also elucidated, providing a reference for the and simulation of different microvascular conditions. Journal Article Journal of Biomechanics 117 110241 Elsevier BV 0021-9290 Microcirculation, Flow Resistance, Porous Media, Outflow Boundary Conditions, Haemodynamics 5 3 2021 2021-03-05 10.1016/j.jbiomech.2021.110241 COLLEGE NANME Mechanical Engineering COLLEGE CODE MECH Swansea University 2021-02-01T17:22:17.2479181 2021-01-11T11:41:26.3201994 College of Engineering Engineering Alberto Coccarelli 0000-0003-1511-9015 1 Supratim Saha 2 Tanjeri Purushotham 3 K. Arul Prakash 4 Perumal Nithiarasu 0000-0002-4901-2980 5 Under embargo Under embargo 2021-02-01T17:19:37.5386226 Output 946660 application/pdf Accepted Manuscript true 2022-01-13T00:00:00.0000000 ©2021 All rights reserved. All article content, except where otherwise noted, is licensed under a Creative Commons Attribution Non-Commercial No Derivatives License (CC-BY-NC-ND) true eng
title On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
spellingShingle On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
Alberto, Coccarelli
Perumal, Nithiarasu
title_short On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
title_full On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
title_fullStr On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
title_full_unstemmed On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
title_sort On the poro-elastic models for microvascular blood flow resistance: An in vitro validation
author_id_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d
3b28bf59358fc2b9bd9a46897dbfc92d
author_id_fullname_str_mv 06fd3332e5eb3cf4bb4e75a24f49149d_***_Alberto, Coccarelli
3b28bf59358fc2b9bd9a46897dbfc92d_***_Perumal, Nithiarasu
author Alberto, Coccarelli
Perumal, Nithiarasu
author2 Alberto Coccarelli
Supratim Saha
Tanjeri Purushotham
K. Arul Prakash
Perumal Nithiarasu
format Journal article
container_title Journal of Biomechanics
container_volume 117
container_start_page 110241
publishDate 2021
institution Swansea University
issn 0021-9290
doi_str_mv 10.1016/j.jbiomech.2021.110241
publisher Elsevier BV
college_str College of Engineering
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hierarchy_top_title College of Engineering
hierarchy_parent_id collegeofengineering
hierarchy_parent_title College of Engineering
department_str Engineering{{{_:::_}}}College of Engineering{{{_:::_}}}Engineering
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description Nowadays, adequate and accurate representation of the microvascular flow resistance constitutes one of the major challenges in computational haemodynamic studies. In this work, a theoretical, porous media framework, ultimately designed for representing downstream resistance, is presented and compared against an in vitro experimental results. The resistor consists of a poro-elastic tube, with either a constant or variable porosity profile in space. The underlying physics, characterizing the fluid flow through the porous media, is analysed by considering flow variables at different network locations. Backward reflections, originated in the reservoir of the in vitro model, are accounted for through a reflection coefficient imposed as an outflow network condition. The simulation results are in good agreement with the measurements for both the homogenous and heterogeneous porosity conditions. In addition, the comparison allows identification of the range of values representing experimental reservoir reflection coefficients. The pressure drops across the heterogeneous porous media increases with respect to the simpler configuration, whilst flow remains almost unchanged. The effect of some fluid network features, such as tube Young’s modulus and fluid viscosity, on the theoretical results is also elucidated, providing a reference for the and simulation of different microvascular conditions.
published_date 2021-03-05T04:19:45Z
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