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Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis

Shane Heffernan Orcid Logo, Gillian E. Conway

Pain Management - Practices, Novel Therapies and Bioactives

Swansea University Author: Shane Heffernan Orcid Logo

DOI (Published version): 10.5772/intechopen.95919

Abstract

Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of join...

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Published in: Pain Management - Practices, Novel Therapies and Bioactives
ISBN: 9781838800260 9781838808976
Published: IntechOpen 2021
Online Access: https://www.intechopen.com/books/pain-management-practices-novel-therapies-and-bioactives/nutraceutical-alternatives-to-pharmaceutical-analgesics-in-osteoarthritis
URI: https://cronfa.swan.ac.uk/Record/cronfa56542
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fullrecord <?xml version="1.0"?><rfc1807><datestamp>2021-04-20T11:52:49.3105936</datestamp><bib-version>v2</bib-version><id>56542</id><entry>2021-03-24</entry><title>Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis</title><swanseaauthors><author><sid>72c0b36891dfbec0378c0d0f7916e807</sid><ORCID>0000-0002-3297-9335</ORCID><firstname>Shane</firstname><surname>Heffernan</surname><name>Shane Heffernan</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2021-03-24</date><deptcode>STSC</deptcode><abstract>Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all &#xFEFF;those over 50 years, globally) and is the most common cause of joint pain. The prevalence of non-steroidal anti-inflammatory drug (NSAIDs) and analgesic use has been well studied and is abundant throughout the western world, with women being the greatest users and ibuprofen generally being the most &#xFEFF;reported NSAID. In the US, 65% of all OA patients are prescribed NSAIDs for pain management and form part of the current recommended strategy for OA clinical management. While some NSAIDs and analgesics are effective at improving pain and physical function, they come with significant and harmful side effects such as gastrointestinal complications, renal disturbances and severe cardiovascular events. Given these side-effects, any reduction in NSAID and analgesia use (and the resulting potentially harmful side effects) is of particular importance to OA public health. As such, a number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function. This chapter will discuss select nutraceuticals that are not currently in mainstream use but may have the potential to aid in the treatment of OA.</abstract><type>Book chapter</type><journal>Pain Management - Practices, Novel Therapies and Bioactives</journal><volume/><journalNumber/><paginationStart/><paginationEnd/><publisher>IntechOpen</publisher><placeOfPublication/><isbnPrint>9781838800260</isbnPrint><isbnElectronic>9781838808976</isbnElectronic><issnPrint/><issnElectronic/><keywords>joint pain, pain medication, non-pharmacological pain management, mechanisms of pain and action, paracetamol (acetaminophen N-acetyl-p-aminophenol; APAP), opioids</keywords><publishedDay>24</publishedDay><publishedMonth>3</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-03-24</publishedDate><doi>10.5772/intechopen.95919</doi><url>https://www.intechopen.com/books/pain-management-practices-novel-therapies-and-bioactives/nutraceutical-alternatives-to-pharmaceutical-analgesics-in-osteoarthritis</url><notes/><college>COLLEGE NANME</college><department>Sport and Exercise Sciences</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>STSC</DepartmentCode><institution>Swansea University</institution><apcterm/><lastEdited>2021-04-20T11:52:49.3105936</lastEdited><Created>2021-03-24T14:06:33.9526978</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Shane</firstname><surname>Heffernan</surname><orcid>0000-0002-3297-9335</orcid><order>1</order></author><author><firstname>Gillian E.</firstname><surname>Conway</surname><order>2</order></author></authors><documents><document><filename>56542__19543__d1aa04da9d274ef387acb61b3368d3ad.pdf</filename><originalFilename>56542.pdf</originalFilename><uploaded>2021-03-24T14:12:47.7926218</uploaded><type>Output</type><contentLength>835750</contentLength><contentType>application/pdf</contentType><version>Accepted Manuscript</version><cronfaStatus>true</cronfaStatus><copyrightCorrect>false</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by-nc-nd/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling 2021-04-20T11:52:49.3105936 v2 56542 2021-03-24 Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false 2021-03-24 STSC Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of joint pain. The prevalence of non-steroidal anti-inflammatory drug (NSAIDs) and analgesic use has been well studied and is abundant throughout the western world, with women being the greatest users and ibuprofen generally being the most reported NSAID. In the US, 65% of all OA patients are prescribed NSAIDs for pain management and form part of the current recommended strategy for OA clinical management. While some NSAIDs and analgesics are effective at improving pain and physical function, they come with significant and harmful side effects such as gastrointestinal complications, renal disturbances and severe cardiovascular events. Given these side-effects, any reduction in NSAID and analgesia use (and the resulting potentially harmful side effects) is of particular importance to OA public health. As such, a number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function. This chapter will discuss select nutraceuticals that are not currently in mainstream use but may have the potential to aid in the treatment of OA. Book chapter Pain Management - Practices, Novel Therapies and Bioactives IntechOpen 9781838800260 9781838808976 joint pain, pain medication, non-pharmacological pain management, mechanisms of pain and action, paracetamol (acetaminophen N-acetyl-p-aminophenol; APAP), opioids 24 3 2021 2021-03-24 10.5772/intechopen.95919 https://www.intechopen.com/books/pain-management-practices-novel-therapies-and-bioactives/nutraceutical-alternatives-to-pharmaceutical-analgesics-in-osteoarthritis COLLEGE NANME Sport and Exercise Sciences COLLEGE CODE STSC Swansea University 2021-04-20T11:52:49.3105936 2021-03-24T14:06:33.9526978 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Shane Heffernan 0000-0002-3297-9335 1 Gillian E. Conway 2 56542__19543__d1aa04da9d274ef387acb61b3368d3ad.pdf 56542.pdf 2021-03-24T14:12:47.7926218 Output 835750 application/pdf Accepted Manuscript true false eng http://creativecommons.org/licenses/by-nc-nd/4.0/
title Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
spellingShingle Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
Shane Heffernan
title_short Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
title_full Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
title_fullStr Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
title_full_unstemmed Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
title_sort Nutraceutical Alternatives to Pharmaceutical Analgesics in Osteoarthritis
author_id_str_mv 72c0b36891dfbec0378c0d0f7916e807
author_id_fullname_str_mv 72c0b36891dfbec0378c0d0f7916e807_***_Shane Heffernan
author Shane Heffernan
author2 Shane Heffernan
Gillian E. Conway
format Book chapter
container_title Pain Management - Practices, Novel Therapies and Bioactives
publishDate 2021
institution Swansea University
isbn 9781838800260
9781838808976
doi_str_mv 10.5772/intechopen.95919
publisher IntechOpen
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
url https://www.intechopen.com/books/pain-management-practices-novel-therapies-and-bioactives/nutraceutical-alternatives-to-pharmaceutical-analgesics-in-osteoarthritis
document_store_str 1
active_str 0
description Chronic pain is a considerable health concern worldwide, effecting almost 30% of all European adults. Osteoarthritis (OA), a progressive pro-inflammatory condition, is one of the leading causes of chronic pain (effecting 13% of all those over 50 years, globally) and is the most common cause of joint pain. The prevalence of non-steroidal anti-inflammatory drug (NSAIDs) and analgesic use has been well studied and is abundant throughout the western world, with women being the greatest users and ibuprofen generally being the most reported NSAID. In the US, 65% of all OA patients are prescribed NSAIDs for pain management and form part of the current recommended strategy for OA clinical management. While some NSAIDs and analgesics are effective at improving pain and physical function, they come with significant and harmful side effects such as gastrointestinal complications, renal disturbances and severe cardiovascular events. Given these side-effects, any reduction in NSAID and analgesia use (and the resulting potentially harmful side effects) is of particular importance to OA public health. As such, a number of non-pharmaceutical alternatives (bioactive nutraceuticals) have been developed that may reduce NSAID and analgesia use while maintaining pain reduction and improvements in physical function. This chapter will discuss select nutraceuticals that are not currently in mainstream use but may have the potential to aid in the treatment of OA.
published_date 2021-03-24T04:11:35Z
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