Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities

Metcalfe, Richard; Kemp, Rachael; Heffernan, Shane; Churm, Rachel; Chen, Yung-Chih; Ruffino, José S.; Conway, Gill; Tornillo, Giusy; Orange, Samuel T.

doi:10.1007/s00421-021-04680-x

Journal article 920 views 92 downloads

Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities

Richard Metcalfe

, Rachael Kemp, Shane Heffernan

, Rachel Churm

, Yung-Chih Chen, José S. Ruffino, Gill Conway

, Giusy Tornillo, Samuel T. Orange

European Journal of Applied Physiology, Volume: 121

Swansea University Authors: Richard Metcalfe , Shane Heffernan , Rachel Churm , Gill Conway

PDF | Version of Record

© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License
Download (2.67MB)

Check full text

DOI (Published version): 10.1007/s00421-021-04680-x

Abstract

Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incub...

Full description

Published in:	European Journal of Applied Physiology
ISSN:	1439-6319 1439-6327
Published:	Springer Science and Business Media LLC 2021
Online Access:	Check full text
URI:	https://cronfa.swan.ac.uk/Record/cronfa56708

first_indexed	2021-04-20T11:41:11Z
last_indexed	2021-08-10T03:15:14Z
id	cronfa56708
recordtype	SURis
fullrecord	<?xml version="1.0"?><rfc1807><datestamp>2021-08-09T15:27:52.6571967</datestamp><bib-version>v2</bib-version><id>56708</id><entry>2021-04-20</entry><title>Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities</title><swanseaauthors><author><sid>9bb783273dd9d54a2f3f66f75c43abdf</sid><ORCID>0000-0003-0980-2977</ORCID><firstname>Richard</firstname><surname>Metcalfe</surname><name>Richard Metcalfe</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>72c0b36891dfbec0378c0d0f7916e807</sid><ORCID>0000-0002-3297-9335</ORCID><firstname>Shane</firstname><surname>Heffernan</surname><name>Shane Heffernan</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>c6cd8267ff0b13f2ea333bbfefdae144</sid><ORCID>0000-0001-9855-6282</ORCID><firstname>Rachel</firstname><surname>Churm</surname><name>Rachel Churm</name><active>true</active><ethesisStudent>false</ethesisStudent></author><author><sid>e33e0ee5a076ad91fe6615117caa1800</sid><ORCID>0000-0002-5991-0960</ORCID><firstname>Gill</firstname><surname>Conway</surname><name>Gill Conway</name><active>true</active><ethesisStudent>false</ethesisStudent></author></swanseaauthors><date>2021-04-20</date><deptcode>EAAS</deptcode><abstract>Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incubation of cancer cells with post-exercise serum can have powerful effects on key hallmarks of cancer cell behaviour in vitro. This suggests that exercise can impact tumour biology through direct changes in circulating proteins, RNA molecules and metabolites. Here, we provide a comprehensive narrative overview of what is known about the effects of exercise-conditioned sera on in vitro cancer cell behaviour. In doing so, we consider the key limitations of the current body of literature, both from the perspective of exercise physiology and cancer biology, and we discuss the potential in vivo physiological relevance of these findings. We propose key opportunities for future research in an area that has the potential to identify key anti-oncogenic protein targets and optimise physical activity recommendations for cancer prevention, treatment and survivorship.</abstract><type>Journal Article</type><journal>European Journal of Applied Physiology</journal><volume>121</volume><journalNumber/><paginationStart/><paginationEnd/><publisher>Springer Science and Business Media LLC</publisher><placeOfPublication/><isbnPrint/><isbnElectronic/><issnPrint>1439-6319</issnPrint><issnElectronic>1439-6327</issnElectronic><keywords>Exercise; Physical activity; Cancer prevention; Cancer therapy; Cancer cell growth; Cancer cell proliferation; Cancer cell apoptosis; Exercise-conditioned serum</keywords><publishedDay>1</publishedDay><publishedMonth>8</publishedMonth><publishedYear>2021</publishedYear><publishedDate>2021-08-01</publishedDate><doi>10.1007/s00421-021-04680-x</doi><url/><notes/><college>COLLEGE NANME</college><department>Engineering and Applied Sciences School</department><CollegeCode>COLLEGE CODE</CollegeCode><DepartmentCode>EAAS</DepartmentCode><institution>Swansea University</institution><apcterm>SU Library paid the OA fee (TA Institutional Deal)</apcterm><lastEdited>2021-08-09T15:27:52.6571967</lastEdited><Created>2021-04-20T12:39:59.3139989</Created><path><level id="1">Faculty of Science and Engineering</level><level id="2">School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences</level></path><authors><author><firstname>Richard</firstname><surname>Metcalfe</surname><orcid>0000-0003-0980-2977</orcid><order>1</order></author><author><firstname>Rachael</firstname><surname>Kemp</surname><order>2</order></author><author><firstname>Shane</firstname><surname>Heffernan</surname><orcid>0000-0002-3297-9335</orcid><order>3</order></author><author><firstname>Rachel</firstname><surname>Churm</surname><orcid>0000-0001-9855-6282</orcid><order>4</order></author><author><firstname>Yung-Chih</firstname><surname>Chen</surname><order>5</order></author><author><firstname>José S.</firstname><surname>Ruffino</surname><order>6</order></author><author><firstname>Gill</firstname><surname>Conway</surname><orcid>0000-0002-5991-0960</orcid><order>7</order></author><author><firstname>Giusy</firstname><surname>Tornillo</surname><order>8</order></author><author><firstname>Samuel T.</firstname><surname>Orange</surname><order>9</order></author></authors><documents><document><filename>56708__20583__215292f441dc413a988130091b520710.pdf</filename><originalFilename>56708.pdf</originalFilename><uploaded>2021-08-09T15:26:57.3915467</uploaded><type>Output</type><contentLength>2798378</contentLength><contentType>application/pdf</contentType><version>Version of Record</version><cronfaStatus>true</cronfaStatus><documentNotes>© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License</documentNotes><copyrightCorrect>true</copyrightCorrect><language>eng</language><licence>http://creativecommons.org/licenses/by/4.0/</licence></document></documents><OutputDurs/></rfc1807>
spelling	2021-08-09T15:27:52.6571967 v2 56708 2021-04-20 Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities 9bb783273dd9d54a2f3f66f75c43abdf 0000-0003-0980-2977 Richard Metcalfe Richard Metcalfe true false 72c0b36891dfbec0378c0d0f7916e807 0000-0002-3297-9335 Shane Heffernan Shane Heffernan true false c6cd8267ff0b13f2ea333bbfefdae144 0000-0001-9855-6282 Rachel Churm Rachel Churm true false e33e0ee5a076ad91fe6615117caa1800 0000-0002-5991-0960 Gill Conway Gill Conway true false 2021-04-20 EAAS Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incubation of cancer cells with post-exercise serum can have powerful effects on key hallmarks of cancer cell behaviour in vitro. This suggests that exercise can impact tumour biology through direct changes in circulating proteins, RNA molecules and metabolites. Here, we provide a comprehensive narrative overview of what is known about the effects of exercise-conditioned sera on in vitro cancer cell behaviour. In doing so, we consider the key limitations of the current body of literature, both from the perspective of exercise physiology and cancer biology, and we discuss the potential in vivo physiological relevance of these findings. We propose key opportunities for future research in an area that has the potential to identify key anti-oncogenic protein targets and optimise physical activity recommendations for cancer prevention, treatment and survivorship. Journal Article European Journal of Applied Physiology 121 Springer Science and Business Media LLC 1439-6319 1439-6327 Exercise; Physical activity; Cancer prevention; Cancer therapy; Cancer cell growth; Cancer cell proliferation; Cancer cell apoptosis; Exercise-conditioned serum 1 8 2021 2021-08-01 10.1007/s00421-021-04680-x COLLEGE NANME Engineering and Applied Sciences School COLLEGE CODE EAAS Swansea University SU Library paid the OA fee (TA Institutional Deal) 2021-08-09T15:27:52.6571967 2021-04-20T12:39:59.3139989 Faculty of Science and Engineering School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences Richard Metcalfe 0000-0003-0980-2977 1 Rachael Kemp 2 Shane Heffernan 0000-0002-3297-9335 3 Rachel Churm 0000-0001-9855-6282 4 Yung-Chih Chen 5 José S. Ruffino 6 Gill Conway 0000-0002-5991-0960 7 Giusy Tornillo 8 Samuel T. Orange 9 56708__20583__215292f441dc413a988130091b520710.pdf 56708.pdf 2021-08-09T15:26:57.3915467 Output 2798378 application/pdf Version of Record true © The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License true eng http://creativecommons.org/licenses/by/4.0/
title	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
spellingShingle	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities Richard Metcalfe Shane Heffernan Rachel Churm Gill Conway
title_short	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
title_full	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
title_fullStr	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
title_full_unstemmed	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
title_sort	Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities
author_id_str_mv	9bb783273dd9d54a2f3f66f75c43abdf 72c0b36891dfbec0378c0d0f7916e807 c6cd8267ff0b13f2ea333bbfefdae144 e33e0ee5a076ad91fe6615117caa1800
author_id_fullname_str_mv	9bb783273dd9d54a2f3f66f75c43abdf_*_Richard Metcalfe 72c0b36891dfbec0378c0d0f7916e807__Shane Heffernan c6cd8267ff0b13f2ea333bbfefdae144__Rachel Churm e33e0ee5a076ad91fe6615117caa1800_*_Gill Conway
author	Richard Metcalfe Shane Heffernan Rachel Churm Gill Conway
author2	Richard Metcalfe Rachael Kemp Shane Heffernan Rachel Churm Yung-Chih Chen José S. Ruffino Gill Conway Giusy Tornillo Samuel T. Orange
format	Journal article
container_title	European Journal of Applied Physiology
container_volume	121
publishDate	2021
institution	Swansea University
issn	1439-6319 1439-6327
doi_str_mv	10.1007/s00421-021-04680-x
publisher	Springer Science and Business Media LLC
college_str	Faculty of Science and Engineering
hierarchytype
hierarchy_top_id	facultyofscienceandengineering
hierarchy_top_title	Faculty of Science and Engineering
hierarchy_parent_id	facultyofscienceandengineering
hierarchy_parent_title	Faculty of Science and Engineering
department_str	School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Aerospace, Civil, Electrical, General and Mechanical Engineering - Sport and Exercise Sciences
document_store_str	1
active_str	0
description	Regular physical activity reduces the risk of several site-specific cancers in humans and suppresses tumour growth in animal models. The mechanisms through which exercise reduces tumour growth remain incompletely understood, but an intriguing and accumulating body of evidence suggests that the incubation of cancer cells with post-exercise serum can have powerful effects on key hallmarks of cancer cell behaviour in vitro. This suggests that exercise can impact tumour biology through direct changes in circulating proteins, RNA molecules and metabolites. Here, we provide a comprehensive narrative overview of what is known about the effects of exercise-conditioned sera on in vitro cancer cell behaviour. In doing so, we consider the key limitations of the current body of literature, both from the perspective of exercise physiology and cancer biology, and we discuss the potential in vivo physiological relevance of these findings. We propose key opportunities for future research in an area that has the potential to identify key anti-oncogenic protein targets and optimise physical activity recommendations for cancer prevention, treatment and survivorship.
published_date	2021-08-01T05:02:17Z
_version_	1821289833974202368
score	11.390808

Anti-carcinogenic effects of exercise-conditioned human serum: evidence, relevance and opportunities

Similar Items