Journal article 891 views 170 downloads
A proof of concept study for machine learning application to stenosis detection
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Sanjay Pant
Medical & Biological Engineering & Computing, Volume: 59, Issue: 10, Pages: 2085 - 2114
Swansea University Authors:
Perumal Nithiarasu , Sanjay Pant
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DOI (Published version): 10.1007/s11517-021-02424-9
Abstract
This proof of concept (PoC) assesses the ability of machine learning (ML) classifiers to predict the presence of a stenosis in a three vessel arterial system consisting of the abdominal aorta bifurcating into the two common iliacs. A virtual patient database (VPD) is created using one-dimensional pu...
| Published in: | Medical & Biological Engineering & Computing |
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| ISSN: | 0140-0118 1741-0444 |
| Published: |
Springer Science and Business Media LLC
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa57550 |
| Abstract: |
This proof of concept (PoC) assesses the ability of machine learning (ML) classifiers to predict the presence of a stenosis in a three vessel arterial system consisting of the abdominal aorta bifurcating into the two common iliacs. A virtual patient database (VPD) is created using one-dimensional pulse wave propagation model of haemodynamics. Four different machine learning (ML) methods are used to train and test a series of classifiers—both binary and multiclass—to distinguish between healthy and unhealthy virtual patients (VPs) using different combinations of pressure and flow-rate measurements. It is found that the ML classifiers achieve specificities larger than 80% and sensitivities ranging from 50 to 75%. The most balanced classifier also achieves an area under the receiver operative characteristic curve of 0.75, outperforming approximately 20 methods used in clinical practice, and thus placing the method as moderately accurate. Other important observations from this study are that (i) few measurements can provide similar classification accuracies compared to the case when more/all the measurements are used; (ii) some measurements are more informative than others for classification; and (iii) a modification of standard methods can result in detection of not only the presence of stenosis, but also the stenosed vessel. |
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| Keywords: |
Arterial disease diagnosis; Machine learning; Virtual patient database; Pulse wave haemodynamics |
| College: |
Faculty of Science and Engineering |
| Funders: |
This work is supported by an Engineering and Physical Science Research Council studentship ref. EP/N509553/1 and an Engineering and Physical Science Research Council grant ref. EP/R010811/1. |
| Issue: |
10 |
| Start Page: |
2085 |
| End Page: |
2114 |