No Cover Image

Journal article 425 views 64 downloads

Molecular insights into the mechanisms of susceptibility of Labeo rohita against oomycete Aphanomyces invadans

P. K. Pradhan, Dev Kumar Verma, Luca Peruzza, Shubham Gupta, Syed Assim Haq, Sergei Shubin Orcid Logo, Kenton L. Morgan, Franziska Trusch, Vindhya Mohindra, Chris Hauton, Pieter van West, Neeraj Sood

Scientific Reports, Volume: 10, Issue: 1

Swansea University Author: Sergei Shubin Orcid Logo

  • 57712.VOR.s41598-020-76278-w.pdf

    PDF | Version of Record

    © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License

    Download (4.55MB)

Abstract

Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one of the most destructive pathogens of freshwater fishes. To date, the disease has been reported from over 160 fish species in 20 countries and notably, this is the first non-salmonid disease that has resulted in major...

Full description

Published in: Scientific Reports
ISSN: 2045-2322
Published: Springer Science and Business Media LLC 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa57712
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Aphanomyces invadans, the causative agent of epizootic ulcerative syndrome, is one of the most destructive pathogens of freshwater fishes. To date, the disease has been reported from over 160 fish species in 20 countries and notably, this is the first non-salmonid disease that has resulted in major impacts globally. In particular, Indian major carps (IMCs) are highly susceptible to this disease. To increase our knowledge particularly with regards to host immune response against A. invadans infection in a susceptible host, the gene expression profile in head kidney of A. invadans-infected and control rohu, Labeo rohita was investigated using RNA sequencing. Time course analysis of RNA-Seq data revealed 5608 differentially expressed genes, involved among others in Antigen processing and presentation, Leukocyte transendothelial migration, IL-17 signaling, Chemokine signaling, C-type lectin receptor signaling and Toll-like receptor signaling pathways. In the affected pathways, a number of immune genes were found to be downregulated, suggesting an immune evasion strategy of A. invadans in establishing the infection. The information generated in this study offers first systematic mechanistic understanding of the host-pathogen interaction that might underpin the development of new management strategies for this economically devastating fish-pathogenic oomycete A. invadans.
College: Faculty of Science and Engineering
Issue: 1