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Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis / Imke A. B. Pijpers, Shoupeng Cao, Antoni Llopis-Lorente, Jianzhi Zhu, Shidong Song, Rick R. M. Joosten, Fenghua Meng, Heiner Friedrich, David Williams, Samuel Sánchez, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen

Nano Letters, Volume: 20, Issue: 6, Pages: 4472 - 4480

Swansea University Author: David Williams

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Abstract

Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presen...

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Published in: Nano Letters
ISSN: 1530-6984 1530-6992
Published: American Chemical Society (ACS) 2020
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa57796
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Abstract: Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO2 nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts.
Keywords: Mechanical Engineering, Condensed Matter Physics, General Materials Science, General Chemistry, Bioengineering
College: College of Science
Funders: Fundaci?n BBVA Identifier: FundRef 10.13039/100007406 Ministerio de Econom?a y Competitividad Identifier: FundRef 10.13039/501100003329 H2020 Marie Sklodowska-Curie Actions Grant: 663830 Identifier: FundRef 10.13039/100010665 Generalitat de Catalunya Identifier: FundRef 10.13039/501100002809 National Natural Science Foundation of China Grant: 51561135010 Identifier: FundRef 10.13039/501100001809 Nederlandse Organisatie voor Wetenschappelijk Onderzoek Grant: 024.001.035 Grant: 792.001.015 Identifier: FundRef 10.13039/501100003246
Issue: 6
Start Page: 4472
End Page: 4480