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Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis

Imke A. B. Pijpers, Shoupeng Cao, Antoni Llopis-Lorente, Jianzhi Zhu, Shidong Song, Rick R. M. Joosten, Fenghua Meng, Heiner Friedrich, David Williams Orcid Logo, Samuel Sánchez, Jan C. M. van Hest, Loai K. E. A. Abdelmohsen

Nano Letters, Volume: 20, Issue: 6, Pages: 4472 - 4480

Swansea University Author: David Williams Orcid Logo

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DOI (Published version): 10.1021/acs.nanolett.0c01268

Abstract

Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presen...

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Published in: Nano Letters
ISSN: 1530-6984 1530-6992
Published: American Chemical Society (ACS) 2020
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URI: https://cronfa.swan.ac.uk/Record/cronfa57796
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Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO2 nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. 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spelling 2021-09-07T11:58:08.3783133 v2 57796 2021-09-07 Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis c9047e773a645b7cb459ac4beedd0a37 0000-0002-8209-6899 David Williams David Williams true false 2021-09-07 SCH Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO2 nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts. Journal Article Nano Letters 20 6 4472 4480 American Chemical Society (ACS) 1530-6984 1530-6992 Mechanical Engineering, Condensed Matter Physics, General Materials Science, General Chemistry, Bioengineering 10 6 2020 2020-06-10 10.1021/acs.nanolett.0c01268 COLLEGE NANME Chemistry COLLEGE CODE SCH Swansea University Other Fundaci?n BBVA Identifier: FundRef 10.13039/100007406 Ministerio de Econom?a y Competitividad Identifier: FundRef 10.13039/501100003329 H2020 Marie Sklodowska-Curie Actions Grant: 663830 Identifier: FundRef 10.13039/100010665 Generalitat de Catalunya Identifier: FundRef 10.13039/501100002809 National Natural Science Foundation of China Grant: 51561135010 Identifier: FundRef 10.13039/501100001809 Nederlandse Organisatie voor Wetenschappelijk Onderzoek Grant: 024.001.035 Grant: 792.001.015 Identifier: FundRef 10.13039/501100003246 2021-09-07T11:58:08.3783133 2021-09-07T11:53:22.4102771 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemistry Imke A. B. Pijpers 1 Shoupeng Cao 2 Antoni Llopis-Lorente 3 Jianzhi Zhu 4 Shidong Song 5 Rick R. M. Joosten 6 Fenghua Meng 7 Heiner Friedrich 8 David Williams 0000-0002-8209-6899 9 Samuel Sánchez 10 Jan C. M. van Hest 11 Loai K. E. A. Abdelmohsen 12 57796__20765__44278d3f8bfd405d8ff10b9c703a69bc.pdf 57796.pdf 2021-09-07T11:55:42.3238158 Output 4871985 application/pdf Version of Record true This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License true eng http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html
title Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
spellingShingle Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
David Williams
title_short Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
title_full Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
title_fullStr Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
title_full_unstemmed Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
title_sort Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
author_id_str_mv c9047e773a645b7cb459ac4beedd0a37
author_id_fullname_str_mv c9047e773a645b7cb459ac4beedd0a37_***_David Williams
author David Williams
author2 Imke A. B. Pijpers
Shoupeng Cao
Antoni Llopis-Lorente
Jianzhi Zhu
Shidong Song
Rick R. M. Joosten
Fenghua Meng
Heiner Friedrich
David Williams
Samuel Sánchez
Jan C. M. van Hest
Loai K. E. A. Abdelmohsen
format Journal article
container_title Nano Letters
container_volume 20
container_issue 6
container_start_page 4472
publishDate 2020
institution Swansea University
issn 1530-6984
1530-6992
doi_str_mv 10.1021/acs.nanolett.0c01268
publisher American Chemical Society (ACS)
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemistry{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemistry
document_store_str 1
active_str 0
description Designer particles that are embued with nanomachinery for autonomous motion have great potential for biomedical applications; however, their development is highly demanding with respect to biodegradability/compatibility. Previously, biodegradable propulsive machinery based on enzymes has been presented. However, enzymes are highly susceptible to proteolysis and deactivation in biological milieu. Biodegradable hybrid nanomotors powered by catalytic inorganic nanoparticles provide a proteolytically stable alternative to those based upon enzymes. Herein we describe the assembly of hybrid biodegradable nanomotors capable of transducing chemical energy into motion. Such nanomotors are constructed through a process of compartmentalized synthesis of inorganic MnO2 nanoparticles (MnPs) within the cavity of organic stomatocytes. We show that the nanomotors remain active in cellular environments and do not compromise cell viability. Effective tumor penetration of hybrid nanomotors is also demonstrated in proof-of-principle experiments. Overall, this work represents a new prospect for engineering of nanomotors that can retain their functionality within biological contexts.
published_date 2020-06-10T04:13:48Z
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score 11.036553

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