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Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development

William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

Frontiers in Physiology, Volume: 12

Swansea University Authors: William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

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Abstract

In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are...

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Published in: Frontiers in Physiology
ISSN: 1664-042X
Published: Frontiers Media SA 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa57898
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Abstract: In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol.
Keywords: 25-hydroxycholesterol, SREBP pathway, INSIG, HMG-CoA reductase, SARS-CoV-2, hedgehogsignalling pathway, cholesterol dependent cytolysin
College: Swansea University Medical School
Funders: This work was supported by the UKRI Biotechnology and Biological Sciences Research Council (BBSRC; grant numbers BB/I001735/1 and BB/N015932/1 to WG and BB/L001942/1 to YW), and the Welsh Government and the European Union through European Structural Funds