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Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development

William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

Frontiers in Physiology, Volume: 12

Swansea University Authors: William Griffiths Orcid Logo, Yuqin Wang Orcid Logo

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Abstract

In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are...

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Published in: Frontiers in Physiology
ISSN: 1664-042X
Published: Frontiers Media SA 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57898
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first_indexed 2021-09-15T09:44:08Z
last_indexed 2022-01-25T04:28:21Z
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spelling 2022-01-24T12:45:53.5904136 v2 57898 2021-09-15 Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development 3316b1d1b524be1831790933eed1c26e 0000-0002-4129-6616 William Griffiths William Griffiths true false c92729b58622f9fdf6a0e7d8f4ce5081 0000-0002-3063-3066 Yuqin Wang Yuqin Wang true false 2021-09-15 BMS In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol. Journal Article Frontiers in Physiology 12 Frontiers Media SA 1664-042X 25-hydroxycholesterol, SREBP pathway, INSIG, HMG-CoA reductase, SARS-CoV-2, hedgehogsignalling pathway, cholesterol dependent cytolysin 8 10 2021 2021-10-08 10.3389/fphys.2021.723224 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University External research funder(s) paid the OA fee (includes OA grants disbursed by the Library) This work was supported by the UKRI Biotechnology and Biological Sciences Research Council (BBSRC; grant numbers BB/I001735/1 and BB/N015932/1 to WG and BB/L001942/1 to YW), and the Welsh Government and the European Union through European Structural Funds 2022-01-24T12:45:53.5904136 2021-09-15T10:41:08.5205189 Swansea University Medical School Medicine William Griffiths 0000-0002-4129-6616 1 Yuqin Wang 0000-0002-3063-3066 2 57898__21115__24d10cf7332a44f6a21c153d7a67cfc6.pdf Griffiths Front Physiol 2021.pdf 2021-10-08T08:31:39.7655734 Output 10459719 application/pdf Version of Record true Copyright © 2021 Griffiths and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. true eng https://creativecommons.org/licenses/by/4.0/
title Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
spellingShingle Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
William Griffiths
Yuqin Wang
title_short Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
title_full Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
title_fullStr Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
title_full_unstemmed Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
title_sort Sterols, Oxysterols, and Accessible Cholesterol: Signalling for Homeostasis, in Immunity and During Development
author_id_str_mv 3316b1d1b524be1831790933eed1c26e
c92729b58622f9fdf6a0e7d8f4ce5081
author_id_fullname_str_mv 3316b1d1b524be1831790933eed1c26e_***_William Griffiths
c92729b58622f9fdf6a0e7d8f4ce5081_***_Yuqin Wang
author William Griffiths
Yuqin Wang
author2 William Griffiths
Yuqin Wang
format Journal article
container_title Frontiers in Physiology
container_volume 12
publishDate 2021
institution Swansea University
issn 1664-042X
doi_str_mv 10.3389/fphys.2021.723224
publisher Frontiers Media SA
college_str Swansea University Medical School
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hierarchy_top_title Swansea University Medical School
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hierarchy_parent_title Swansea University Medical School
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description In this article we discuss the concept of accessible plasma membrane cholesterol and its involvement as a signalling molecule. Changes in plasma membrane accessible cholesterol, although only being minor in the context of total cholesterol plasma membrane cholesterol and total cell cholesterol, are a key regulator of overall cellular cholesterol homeostasis by the SREBP pathway. Accessible cholesterol also provides the second messenger between patched 1 and smoothened in the hedgehog signalling pathway important during development, and its depletion may provide a mechanism of resistance to microbial pathogens including SARS-CoV-2. We revise the hypothesis that oxysterols are a signalling form of cholesterol, in this instance as a rapidly acting and paracrine version of accessible cholesterol.
published_date 2021-10-08T04:30:54Z
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