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Clinical Functional Genomics

Seren Carpenter, Steve Conlan Orcid Logo

Cancers, Volume: 13, Issue: 18, Start page: 4627

Swansea University Author: Steve Conlan Orcid Logo

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Abstract

Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the...

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Published in: Cancers
ISSN: 2072-6694
Published: MDPI AG 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa57903
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Abstract: Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the genome leading to expression of particular phenotypes. By studying whole genomes—clinical genomics, transcriptomes and epigenomes—functional genomics allows the exploration of the diverse relationship between genotype and phenotype, not only for humans as a species but also in individuals, allowing an understanding and evaluation of how the functional genome ‘contributes’ to different diseases. Functional variation in disease can help us better understand that disease, although it is currently limited in terms of ethnic diversity, and will ultimately give way to more personalized treatment plans.
Keywords: functional genomics; clinical adoption; CRISPR; single cell analysis; ethnic diversity
College: Swansea University Medical School
Funders: This research was funded by the Swansea University Employability Academy Internship Programme 2021 (S.C.)
Issue: 18
Start Page: 4627