Journal article 46009 views 107 downloads
Clinical Functional Genomics
Cancers, Volume: 13, Issue: 18, Start page: 4627
Swansea University Author:
Steve Conlan
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© 2021 by the authors. This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
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DOI (Published version): 10.3390/cancers13184627
Abstract
Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the...
| Published in: | Cancers |
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| ISSN: | 2072-6694 |
| Published: |
MDPI AG
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa57903 |
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| Abstract: |
Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the genome leading to expression of particular phenotypes. By studying whole genomes—clinical genomics, transcriptomes and epigenomes—functional genomics allows the exploration of the diverse relationship between genotype and phenotype, not only for humans as a species but also in individuals, allowing an understanding and evaluation of how the functional genome ‘contributes’ to different diseases. Functional variation in disease can help us better understand that disease, although it is currently limited in terms of ethnic diversity, and will ultimately give way to more personalized treatment plans. |
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| Keywords: |
functional genomics; clinical adoption; CRISPR; single cell analysis; ethnic diversity |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
This research was funded by the Swansea University Employability Academy Internship Programme 2021 (S.C.) |
| Issue: |
18 |
| Start Page: |
4627 |