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Clinical Functional Genomics

Seren Carpenter, Steve Conlan Orcid Logo

Cancers, Volume: 13, Issue: 18, Start page: 4627

Swansea University Author: Steve Conlan Orcid Logo

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DOI (Published version): 10.3390/cancers13184627

Abstract

Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the...

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Published in: Cancers
ISSN: 2072-6694
Published: MDPI AG 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57903
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first_indexed 2021-09-28T16:42:39Z
last_indexed 2021-09-29T03:22:14Z
id cronfa57903
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spelling 2021-09-28T17:48:28.9177743 v2 57903 2021-09-16 Clinical Functional Genomics 0bb6bd247e32fb4249de62c0013b51cb 0000-0002-2562-3461 Steve Conlan Steve Conlan true false 2021-09-16 BMS Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the genome leading to expression of particular phenotypes. By studying whole genomes—clinical genomics, transcriptomes and epigenomes—functional genomics allows the exploration of the diverse relationship between genotype and phenotype, not only for humans as a species but also in individuals, allowing an understanding and evaluation of how the functional genome ‘contributes’ to different diseases. Functional variation in disease can help us better understand that disease, although it is currently limited in terms of ethnic diversity, and will ultimately give way to more personalized treatment plans. Journal Article Cancers 13 18 4627 MDPI AG 2072-6694 functional genomics; clinical adoption; CRISPR; single cell analysis; ethnic diversity 15 9 2021 2021-09-15 10.3390/cancers13184627 COLLEGE NANME Biomedical Sciences COLLEGE CODE BMS Swansea University This research was funded by the Swansea University Employability Academy Internship Programme 2021 (S.C.) 2021-09-28T17:48:28.9177743 2021-09-16T07:50:03.2665560 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Seren Carpenter 1 Steve Conlan 0000-0002-2562-3461 2 57903__21044__0c09a9e74db5494e99bc09b560d833b0.pdf 57903.pdf 2021-09-28T17:46:09.6584710 Output 1166767 application/pdf Version of Record true © 2021 by the authors. This is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license true eng https://creativecommons.org/licenses/by/4.0/
title Clinical Functional Genomics
spellingShingle Clinical Functional Genomics
Steve Conlan
title_short Clinical Functional Genomics
title_full Clinical Functional Genomics
title_fullStr Clinical Functional Genomics
title_full_unstemmed Clinical Functional Genomics
title_sort Clinical Functional Genomics
author_id_str_mv 0bb6bd247e32fb4249de62c0013b51cb
author_id_fullname_str_mv 0bb6bd247e32fb4249de62c0013b51cb_***_Steve Conlan
author Steve Conlan
author2 Seren Carpenter
Steve Conlan
format Journal article
container_title Cancers
container_volume 13
container_issue 18
container_start_page 4627
publishDate 2021
institution Swansea University
issn 2072-6694
doi_str_mv 10.3390/cancers13184627
publisher MDPI AG
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description Functional genomics is the study of how the genome and its products, including RNA and proteins, function and interact to affect different biological processes. The field of functional genomics includes transcriptomics, proteomics, metabolomics and epigenomics, as these all relate to controlling the genome leading to expression of particular phenotypes. By studying whole genomes—clinical genomics, transcriptomes and epigenomes—functional genomics allows the exploration of the diverse relationship between genotype and phenotype, not only for humans as a species but also in individuals, allowing an understanding and evaluation of how the functional genome ‘contributes’ to different diseases. Functional variation in disease can help us better understand that disease, although it is currently limited in terms of ethnic diversity, and will ultimately give way to more personalized treatment plans.
published_date 2021-09-15T04:13:59Z
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score 11.03559

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