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The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments

Lin Qi, Wenbo Zhu, Wei Qian, Lisheng Xu, Ying He, Feihu Zhao Orcid Logo

Frontiers in Physiology, Volume: 12

Swansea University Author: Feihu Zhao Orcid Logo

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Abstract

At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is si...

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Published in: Frontiers in Physiology
ISSN: 1664-042X
Published: Frontiers Media SA 2021
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URI: https://cronfa.swan.ac.uk/Record/cronfa57927
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spelling 2021-09-28T16:48:12.6974408 v2 57927 2021-09-16 The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments 1c6e79b6edd08c88a8d17a241cd78630 0000-0003-0515-6808 Feihu Zhao Feihu Zhao true false 2021-09-16 MEDE At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is situated in the curved part of the vessel. To improve the performance of traditional post-dilation balloon catheter, a preliminary design of a novel catheter with a spherical-tip is proposed. Since the performance of this spherical-tip catheter is still unclear, in this study, finite element analysis (FEA) and experimental validation of blood vessel with different curvature radii were performed to test and evaluate the performance of the spherical-tip catheter design. The comparative results between the two types of catheters demonstrate that in the simulated post-dilation process, the spherical-tip catheter is easier to pass through the stent placed in the curved vessel without the deformation of the stent strut, and can theoretically reduce the operation time and improve the safety of the operation. Furthermore, the strong consistency between simulation and experiment indicates that the finite element (FE) model can be a helpful tool for future optimization and evaluation of novel catheters, so as to save time and budget in product development and reduce/replace animal studies. Journal Article Frontiers in Physiology 12 Frontiers Media SA 1664-042X Physiology, post-dilation, spherical-tip catheter, finite element analysis, percutaneous coronary intervention, finite element model 31 8 2021 2021-08-31 10.3389/fphys.2021.734565 COLLEGE NANME Biomedical Engineering COLLEGE CODE MEDE Swansea University National Key Research and Development Program of China; National Natural Science Foundation of China; Fundamental Research Funds for the Central Universities; Open Grant by National Health Commission Key Laboratory of Assisted Circulation (Sun Yat-sen University) 2020YFC2004400; No. 61773110; No. N2119008; No. cvclab201901 2021-09-28T16:48:12.6974408 2021-09-16T16:16:11.0793057 Faculty of Science and Engineering School of Engineering and Applied Sciences - Biomedical Engineering Lin Qi 1 Wenbo Zhu 2 Wei Qian 3 Lisheng Xu 4 Ying He 5 Feihu Zhao 0000-0003-0515-6808 6 57927__20894__9c1897ac38d5441382858325daeded28.pdf fphys-12-734565.pdf 2021-09-16T16:16:11.0789872 Output 4462722 application/pdf Version of Record true © 2021 Qi, Zhu, Qian, Xu, He and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) true eng http://creativecommons.org/licenses/by/4.0/
title The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
spellingShingle The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
Feihu Zhao
title_short The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_full The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_fullStr The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_full_unstemmed The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
title_sort The Performance of a Spherical-tip Catheter for Stent Post-dilation: Finite Element Analysis and Experiments
author_id_str_mv 1c6e79b6edd08c88a8d17a241cd78630
author_id_fullname_str_mv 1c6e79b6edd08c88a8d17a241cd78630_***_Feihu Zhao
author Feihu Zhao
author2 Lin Qi
Wenbo Zhu
Wei Qian
Lisheng Xu
Ying He
Feihu Zhao
format Journal article
container_title Frontiers in Physiology
container_volume 12
publishDate 2021
institution Swansea University
issn 1664-042X
doi_str_mv 10.3389/fphys.2021.734565
publisher Frontiers Media SA
college_str Faculty of Science and Engineering
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hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Biomedical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Biomedical Engineering
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description At present, percutaneous coronary intervention (PCI) is the most effective treatment of coronary artery stenosis. However, in case post-dilation of the stent is needed, the tip of the commonly used post-dilation balloon catheter cannot always pass through the stent smoothly, especially when it is situated in the curved part of the vessel. To improve the performance of traditional post-dilation balloon catheter, a preliminary design of a novel catheter with a spherical-tip is proposed. Since the performance of this spherical-tip catheter is still unclear, in this study, finite element analysis (FEA) and experimental validation of blood vessel with different curvature radii were performed to test and evaluate the performance of the spherical-tip catheter design. The comparative results between the two types of catheters demonstrate that in the simulated post-dilation process, the spherical-tip catheter is easier to pass through the stent placed in the curved vessel without the deformation of the stent strut, and can theoretically reduce the operation time and improve the safety of the operation. Furthermore, the strong consistency between simulation and experiment indicates that the finite element (FE) model can be a helpful tool for future optimization and evaluation of novel catheters, so as to save time and budget in product development and reduce/replace animal studies.
published_date 2021-08-31T04:14:02Z
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