No Cover Image

Journal article 96 views 24 downloads

Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo

Paul Rees Orcid Logo, Guillermo Bauza‐Mayol, Marcos Quintela Vazquez, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emman Thomson, Thomas Jovic, Paul Rees, Ennio Tasciotti, Lewis Francis Orcid Logo, Patrick Mcculloch, Francesca Taraballi

Advanced Healthcare Materials, Volume: 11, Issue: 1, Start page: 2101127

Swansea University Authors: Paul Rees Orcid Logo, Marcos Quintela Vazquez, Emman Thomson, Thomas Jovic, Lewis Francis Orcid Logo

  • 58476.pdf

    PDF | Version of Record

    © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License

    Download (7.55MB)

Check full text

DOI (Published version): 10.1002/adhm.202101127

Abstract

Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation...

Full description

Published in: Advanced Healthcare Materials
ISSN: 2192-2640 2192-2659
Published: Wiley 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa58476
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract: Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration.
Keywords: cartilage repair; osteoarthritis; scaffolds; tissue engineering
College: Swansea University Medical School
Funders: Cullen Trust for Health Care Foundation. Grant Number: 18130014; Houston Methodist Hospital
Issue: 1
Start Page: 2101127