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Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo
Advanced Healthcare Materials, Volume: 11, Issue: 1, Start page: 2101127
Swansea University Authors:
Marcos Quintela Vazquez, Emman Thomson, Thomas Jovic, Paul Rees , Lewis Francis
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© 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License.
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DOI (Published version): 10.1002/adhm.202101127
Abstract
Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation...
Published in: | Advanced Healthcare Materials |
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ISSN: | 2192-2640 2192-2659 |
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Wiley
2022
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URI: | https://cronfa.swan.ac.uk/Record/cronfa58476 |
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2025-04-15T13:22:30.5761546 v2 58476 2021-10-27 Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo 29d006fa16d293ca29762fce9c356f8e Marcos Quintela Vazquez Marcos Quintela Vazquez true false dc9e7718f6f8bb11d3df1d0cd8245318 Emman Thomson Emman Thomson true false 7d95ed2bceb18fc0fdfd4048277c6eed Thomas Jovic Thomas Jovic true false 537a2fe031a796a3bde99679ee8c24f5 0000-0002-7715-6914 Paul Rees Paul Rees true false 10f61f9c1248951c1a33f6a89498f37d 0000-0002-7803-7714 Lewis Francis Lewis Francis true false 2021-10-27 ONDF Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration. Journal Article Advanced Healthcare Materials 11 1 2101127 Wiley 2192-2640 2192-2659 cartilage repair; osteoarthritis; scaffolds; tissue engineering 5 1 2022 2022-01-05 10.1002/adhm.202101127 COLLEGE NANME Other/Subsidiary Companies - Not Defined COLLEGE CODE ONDF Swansea University Cullen Trust for Health Care Foundation. Grant Number: 18130014; Houston Methodist Hospital 2025-04-15T13:22:30.5761546 2021-10-27T13:54:37.5124300 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Guillermo Bauza‐Mayol 1 Marcos Quintela Vazquez 2 Ava Brozovich 3 Michael Hopson 4 Shazad Shaikh 5 Fernando Cabrera 6 Aaron Shi 7 Federica Banche Niclot 8 Francesca Paradiso 9 Emman Thomson 10 Thomas Jovic 11 Paul Rees 0000-0002-7715-6914 12 Ennio Tasciotti 13 Lewis Francis 0000-0002-7803-7714 14 Patrick Mcculloch 15 Francesca Taraballi 0000-0002-4959-1169 16 58476__21368__9508b820b4344c87b2f37165302b9ea3.pdf 58476.pdf 2021-10-29T13:15:48.3300117 Output 7915588 application/pdf Version of Record true © 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License. true eng http://creativecommons.org/licenses/by/4.0/ |
title |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
spellingShingle |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo Marcos Quintela Vazquez Emman Thomson Thomas Jovic Paul Rees Lewis Francis |
title_short |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
title_full |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
title_fullStr |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
title_full_unstemmed |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
title_sort |
Biomimetic Scaffolds Modulate the Posttraumatic Inflammatory Response in Articular Cartilage Contributing to Enhanced Neoformation of Cartilaginous Tissue In Vivo |
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29d006fa16d293ca29762fce9c356f8e dc9e7718f6f8bb11d3df1d0cd8245318 7d95ed2bceb18fc0fdfd4048277c6eed 537a2fe031a796a3bde99679ee8c24f5 10f61f9c1248951c1a33f6a89498f37d |
author_id_fullname_str_mv |
29d006fa16d293ca29762fce9c356f8e_***_Marcos Quintela Vazquez dc9e7718f6f8bb11d3df1d0cd8245318_***_Emman Thomson 7d95ed2bceb18fc0fdfd4048277c6eed_***_Thomas Jovic 537a2fe031a796a3bde99679ee8c24f5_***_Paul Rees 10f61f9c1248951c1a33f6a89498f37d_***_Lewis Francis |
author |
Marcos Quintela Vazquez Emman Thomson Thomas Jovic Paul Rees Lewis Francis |
author2 |
Guillermo Bauza‐Mayol Marcos Quintela Vazquez Ava Brozovich Michael Hopson Shazad Shaikh Fernando Cabrera Aaron Shi Federica Banche Niclot Francesca Paradiso Emman Thomson Thomas Jovic Paul Rees Ennio Tasciotti Lewis Francis Patrick Mcculloch Francesca Taraballi |
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Advanced Healthcare Materials |
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description |
Focal chondral lesions of the knee are the most frequent type of trauma in younger patients and are associated with a high risk of developing early posttraumatic osteoarthritis. The only current clinical solutions include microfracture, osteochondral grafting, and autologous chondrocyte implantation. Cartilage tissue engineering based on biomimetic scaffolds has become an appealing strategy to repair cartilage defects. Here, a chondrogenic collagen-chondroitin sulfate scaffold is tested in an orthotopic Lapine in vivo model to understand the beneficial effects of the immunomodulatory biomaterial on the full chondral defect. Using a combination of noninvasive imaging techniques, histological and whole transcriptome analysis, the scaffolds are shown to enhance the formation of cartilaginous tissue and suppression of host cartilage degeneration, while also supporting tissue integration and increased tissue regeneration over a 12 weeks recovery period. The results presented suggest that biomimetic materials could be a clinical solution for cartilage tissue repair, due to their ability to modulate the immune environment in favor of regenerative processes and suppression of cartilage degeneration. |
published_date |
2022-01-05T07:51:50Z |
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11.058267 |