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Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?
,
Nick Jones ,
Cathy Thornton
Immunometabolism, Volume: 3, Issue: 4, Start page: e210031
Swansea University Authors:
Benjamin Jenkins, April Rees , Nick Jones , Cathy Thornton
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DOI (Published version): 10.20900/immunometab20210031
Abstract
Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are th...
| Published in: | Immunometabolism |
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| ISSN: | 2084-6835 2633-0407 |
| Published: |
Hapres
2021
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa58734 |
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| Abstract: |
Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy. |
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| Keywords: |
immunometabolism, maternal metabolism, pregnancy, Treg, Th2 |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Swansea University Research Excellence Scholarship; Ser Cymru II, Welsh Government and MRC (MR/V037013) |
| Issue: |
4 |
| Start Page: |
e210031 |