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Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
,
Zoe Pikramenou
Chemistry – A European Journal, Volume: 28, Issue: 4
Swansea University Authors:
Francesco Graglia, Paolo Bertoncello
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DOI (Published version): 10.1002/chem.202103541
Abstract
Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to m...
| Published in: | Chemistry – A European Journal |
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| ISSN: | 0947-6539 1521-3765 |
| Published: |
Wiley
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa58775 |
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| Abstract: |
Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to monosaccharide binding in aqueous solution. The complex displays orange luminescence at 618 nm, which is reduced by 70 and 40 % upon binding of fructose and glucose, respectively. The electro-chemiluminescent signal of the complex also shows a direct response to monosaccharide binding. The IrIII complex shows the same response upon incorporation into hydrogel matrices as in solution, thus demonstrating the potential of its integration into a device, as a nontoxic, simple-to-use tool to observe sugar binding over physiologically relevant pH ranges and saccharide concentrations. Moreover, the complex's luminescence is responsive to monosaccharide presence in cancer cells. |
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| Keywords: |
electro-chemiluminescence; iridium; luminescence; probes; saccharides; sensors |
| College: |
Faculty of Science and Engineering |
| Funders: |
The authors wish to thank EPSRC and the University of Birmingham for support of the studentship (A.J.C.). |
| Issue: |
4 |