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Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection

Andrew J. Carrod, Francesco Graglia, Louise Male, Cécile Le Duff, Peter Simpson, Mohamed Elsherif, Zubair Ahmed, Haider Butt, Guang‐Xi Xu, Kenneth Kam‐Wing Lo, Paolo Bertoncello Orcid Logo, Zoe Pikramenou Orcid Logo

Chemistry – A European Journal, Volume: 28, Issue: 4

Swansea University Authors: Francesco Graglia, Paolo Bertoncello Orcid Logo

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DOI (Published version): 10.1002/chem.202103541

Abstract

Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to m...

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Published in: Chemistry – A European Journal
ISSN: 0947-6539 1521-3765
Published: Wiley 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa58775
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spelling 2022-10-31T15:40:53.7368272 v2 58775 2021-11-24 Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection f6e814e205ae57ebf54721c4b80a6022 Francesco Graglia Francesco Graglia true false ad352842aa5fe9c1947bd24ff61816c8 0000-0002-6557-7885 Paolo Bertoncello Paolo Bertoncello true false 2021-11-24 Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to monosaccharide binding in aqueous solution. The complex displays orange luminescence at 618 nm, which is reduced by 70 and 40 % upon binding of fructose and glucose, respectively. The electro-chemiluminescent signal of the complex also shows a direct response to monosaccharide binding. The IrIII complex shows the same response upon incorporation into hydrogel matrices as in solution, thus demonstrating the potential of its integration into a device, as a nontoxic, simple-to-use tool to observe sugar binding over physiologically relevant pH ranges and saccharide concentrations. Moreover, the complex's luminescence is responsive to monosaccharide presence in cancer cells. Journal Article Chemistry – A European Journal 28 4 Wiley 0947-6539 1521-3765 electro-chemiluminescence; iridium; luminescence; probes; saccharides; sensors 19 1 2022 2022-01-19 10.1002/chem.202103541 COLLEGE NANME COLLEGE CODE Swansea University The authors wish to thank EPSRC and the University of Birmingham for support of the studentship (A.J.C.). 2022-10-31T15:40:53.7368272 2021-11-24T14:41:05.7098512 Faculty of Science and Engineering School of Engineering and Applied Sciences - Chemical Engineering Andrew J. Carrod 1 Francesco Graglia 2 Louise Male 3 Cécile Le Duff 4 Peter Simpson 5 Mohamed Elsherif 6 Zubair Ahmed 7 Haider Butt 8 Guang‐Xi Xu 9 Kenneth Kam‐Wing Lo 10 Paolo Bertoncello 0000-0002-6557-7885 11 Zoe Pikramenou 0000-0002-6001-1380 12 58775__22250__f6ef214da76f4b79a0672d13b58636fc.pdf 58775.pdf 2022-01-31T09:18:06.2615416 Output 1380787 application/pdf Version of Record true Copyright: 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License true eng http://creativecommons.org/licenses/by/4.0/
title Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
spellingShingle Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
Francesco Graglia
Paolo Bertoncello
title_short Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
title_full Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
title_fullStr Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
title_full_unstemmed Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
title_sort Photo‐ and Electrochemical Dual‐Responsive Iridium Probe for Saccharide Detection
author_id_str_mv f6e814e205ae57ebf54721c4b80a6022
ad352842aa5fe9c1947bd24ff61816c8
author_id_fullname_str_mv f6e814e205ae57ebf54721c4b80a6022_***_Francesco Graglia
ad352842aa5fe9c1947bd24ff61816c8_***_Paolo Bertoncello
author Francesco Graglia
Paolo Bertoncello
author2 Andrew J. Carrod
Francesco Graglia
Louise Male
Cécile Le Duff
Peter Simpson
Mohamed Elsherif
Zubair Ahmed
Haider Butt
Guang‐Xi Xu
Kenneth Kam‐Wing Lo
Paolo Bertoncello
Zoe Pikramenou
format Journal article
container_title Chemistry – A European Journal
container_volume 28
container_issue 4
publishDate 2022
institution Swansea University
issn 0947-6539
1521-3765
doi_str_mv 10.1002/chem.202103541
publisher Wiley
college_str Faculty of Science and Engineering
hierarchytype
hierarchy_top_id facultyofscienceandengineering
hierarchy_top_title Faculty of Science and Engineering
hierarchy_parent_id facultyofscienceandengineering
hierarchy_parent_title Faculty of Science and Engineering
department_str School of Engineering and Applied Sciences - Chemical Engineering{{{_:::_}}}Faculty of Science and Engineering{{{_:::_}}}School of Engineering and Applied Sciences - Chemical Engineering
document_store_str 1
active_str 0
description Dual detection systems are of interest for rapid, accurate data collection in sensing systems and in vitro testing. We introduce an IrIII complex with a boronic acid receptor site attached to the 2-phenylpyridine ligand as an ideal probe with photo- and electrochemical signals that is sensitive to monosaccharide binding in aqueous solution. The complex displays orange luminescence at 618 nm, which is reduced by 70 and 40 % upon binding of fructose and glucose, respectively. The electro-chemiluminescent signal of the complex also shows a direct response to monosaccharide binding. The IrIII complex shows the same response upon incorporation into hydrogel matrices as in solution, thus demonstrating the potential of its integration into a device, as a nontoxic, simple-to-use tool to observe sugar binding over physiologically relevant pH ranges and saccharide concentrations. Moreover, the complex's luminescence is responsive to monosaccharide presence in cancer cells.
published_date 2022-01-19T04:15:35Z
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score 11.016235

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