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Intestinal microbiota and their metabolic contribution to type 2 diabetes and obesity

Andrew Cunningham, Jeffrey Stephens Orcid Logo, Dean Harris Orcid Logo

Journal of Diabetes & Metabolic Disorders, Volume: 20, Issue: 2, Pages: 1855 - 1870

Swansea University Authors: Andrew Cunningham, Jeffrey Stephens Orcid Logo, Dean Harris Orcid Logo

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Abstract

Obesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both ani...

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Published in: Journal of Diabetes & Metabolic Disorders
ISSN: 2251-6581
Published: Springer Science and Business Media LLC 2021
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa58890
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Abstract: Obesity and type 2 diabetes mellitus (T2DM) are common, chronic metabolic disorders with associated significant long-term health problems at global epidemic levels. It is recognised that gut microbiota play a central role in maintaining host homeostasis and through technological advances in both animal and human models it is becoming clear that gut microbiota are heavily involved in key pathophysiological roles in the aetiology and progression of both conditions. This review will focus on current knowledge regarding microbiota interactions with short chain fatty acids, the host inflammatory response, signaling pathways, integrity of the intestinal barrier, the interaction of the gut-brain axis and the subsequent impact on the metabolic health of the host.
Keywords: Gut microbiota; Obesity; Type two diabetes mellitus
College: Swansea University Medical School
Issue: 2
Start Page: 1855
End Page: 1870