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COVID-19 vaccine uptake, effectiveness, and waning in 82,959 health care workers: A national prospective cohort study in Wales

Stuart Bedston, Ashley Akbari Orcid Logo, Christopher I. Jarvis, Emily Lowthian, Fatemeh Torabi Orcid Logo, Laura North, Jane Lyons, Malorie Perry Orcid Logo, Lucy Griffiths Orcid Logo, Rhiannon Owen Orcid Logo, Jillian Beggs, Antony Chuter Orcid Logo, Declan T. Bradley, Simon de Lusignan, Rich Fry Orcid Logo, F.D. Richard Hobbs, Joe Hollinghurst, Srinivasa Vittal Katikireddi, Siobhán Murphy Orcid Logo, Dermot O'Reily Orcid Logo, Chris Robertson, Ting Shi Orcid Logo, Ruby S.M. Tsang, Aziz Sheikh, Ronan Lyons Orcid Logo

Vaccine, Volume: 40, Issue: 8, Pages: 1180 - 1189

Swansea University Authors: Stuart Bedston, Ashley Akbari Orcid Logo, Emily Lowthian, Fatemeh Torabi Orcid Logo, Laura North, Jane Lyons, Lucy Griffiths Orcid Logo, Rhiannon Owen Orcid Logo, Rich Fry Orcid Logo, Joe Hollinghurst, Ronan Lyons Orcid Logo

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Abstract

BackgroundWhile population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of SARS-CoV-2 exposure, is less understood.MethodsWe conducted a national cohort study of health care workers in Wales (UK) from 7 Dece...

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Published in: Vaccine
ISSN: 0264-410X
Published: Elsevier BV 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59218
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Abstract: BackgroundWhile population estimates suggest high vaccine effectiveness against SARS-CoV-2 infection, the protection for health care workers, who are at higher risk of SARS-CoV-2 exposure, is less understood.MethodsWe conducted a national cohort study of health care workers in Wales (UK) from 7 December 2020 to 30 September 2021. We examined uptake of any COVID-19 vaccine, and the effectiveness of BNT162b2 mRNA (Pfizer-BioNTech) against polymerase chain reaction (PCR) confirmed SARS-CoV-2 infection. We used linked and routinely collected national-scale data within the SAIL Databank. Data were available on 82,959 health care workers in Wales, with exposure extending to 26 weeks after second doses.ResultsOverall vaccine uptake was high (90%), with most health care workers receiving the BNT162b2 vaccine (79%). Vaccine uptake differed by age, staff role, socioeconomic status; those aged 50–59 and 60+ years old were 1.6 times more likely to get vaccinated than those aged 16–29. Medical and dental staff, and Allied Health Practitioners were 1.5 and 1.1 times more likely to get vaccinated, compared to nursing and midwifery staff. The effectiveness of the BNT162b2 vaccine was found to be strong and consistent across the characteristics considered; 52% three to six weeks after first dose, 86% from two weeks after second dose, though this declined to 53% from 22 weeks after the second dose.ConclusionsWith some variation in rate of uptake, those who were vaccinated had a reduced risk of PCR-confirmed SARS-CoV-2 infection, compared to those unvaccinated. Second dose has provided stronger protection for longer than first dose but our study is consistent with waning from seven weeks onwards.
Keywords: COVID-19; Health care workers; Vaccines; Pandemic
College: Swansea University Medical School
Funders: WT_/Wellcome Trust/United Kingdom, MR/V028367/1/MRC_/Medical Research Council/United Kingdom, BHF_/British Heart Foundation/United Kingdom.
Issue: 8
Start Page: 1180
End Page: 1189