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Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
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Amy Beynon,
Mariah J. Lelos ,
Gaynor A. Smith ,
Luke Roberts,
Lyndsey Phelps,
Stephen B. Dunnett ,
Alwena Morgan ,
Rowan Brown ,
Timothy Wells ,
Jeffrey Davies
Cellular and Molecular Neurobiology
Swansea University Authors:
Daniel Rees , Amy Beynon, Luke Roberts, Alwena Morgan , Rowan Brown , Jeffrey Davies
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DOI (Published version): 10.1007/s10571-022-01282-9
Abstract
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic...
| Published in: | Cellular and Molecular Neurobiology |
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| ISSN: | 0272-4340 1573-6830 |
| Published: |
Springer Science and Business Media LLC
2022
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| Online Access: |
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59475 |
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| Abstract: |
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD. |
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| Item Description: |
Brief Communication |
| Keywords: |
Acyl-ghrelin, 6-OHDA, Parkinson’s disease |
| College: |
Faculty of Medicine, Health and Life Sciences |
| Funders: |
Parkinson's UK, Grant number: K1008, K1008 |