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Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease

Daniel Rees Orcid Logo, Amy Beynon, Mariah J. Lelos Orcid Logo, Gaynor A. Smith Orcid Logo, Luke Roberts, Lyndsey Phelps, Stephen B. Dunnett Orcid Logo, Alwena Morgan Orcid Logo, Rowan Brown Orcid Logo, Timothy Wells Orcid Logo, Jeffrey Davies Orcid Logo

Cellular and Molecular Neurobiology

Swansea University Authors: Daniel Rees Orcid Logo, Amy Beynon, Luke Roberts, Alwena Morgan Orcid Logo, Rowan Brown Orcid Logo, Jeffrey Davies Orcid Logo

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Abstract

The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic...

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Published in: Cellular and Molecular Neurobiology
ISSN: 0272-4340 1573-6830
Published: Springer Science and Business Media LLC 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa59475
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Abstract: The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD.
Item Description: Brief Communication
Keywords: Acyl-ghrelin, 6-OHDA, Parkinson’s disease
College: Faculty of Medicine, Health and Life Sciences
Funders: Parkinson's UK, Grant number: K1008, K1008