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Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease

Amy Johnson, Daniel Rees Orcid Logo, Amy Beynon, Mariah J. Lelos Orcid Logo, Gaynor A. Smith Orcid Logo, Luke Roberts, Lyndsey Phelps, Stephen B. Dunnett Orcid Logo, Alwena Morgan Orcid Logo, Rowan Brown Orcid Logo, Timothy Wells Orcid Logo, Jeffrey Davies Orcid Logo

Cellular and Molecular Neurobiology, Volume: 43

Swansea University Authors: Amy Johnson, Daniel Rees Orcid Logo, Amy Beynon, Luke Roberts, Alwena Morgan Orcid Logo, Rowan Brown Orcid Logo, Jeffrey Davies Orcid Logo

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DOI (Published version): 10.1007/s10571-022-01282-9

Abstract

The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic...

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Published in: Cellular and Molecular Neurobiology
ISSN: 0272-4340 1573-6830
Published: Springer Science and Business Media LLC 2022
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URI: https://cronfa.swan.ac.uk/Record/cronfa59475
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However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. 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spelling v2 59475 2022-03-01 Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease cd71e22a01d9a5d7e46cd8ef0fc28da1 Amy Johnson Amy Johnson true false daa6762111f9ebf62b9c2ec655512783 0000-0003-0372-6096 Daniel Rees Daniel Rees true false aefec476b7e8ca62f99c89dabd4bdf80 Amy Beynon Amy Beynon true false 22576ee8492628137b76a5b8cb68a384 Luke Roberts Luke Roberts true false 9ea39c3d0935c897cb9fcd3ba550af71 0000-0002-3441-5357 Alwena Morgan Alwena Morgan true false d7db8d42c476dfa69c15ce06d29bd863 0000-0003-3628-2524 Rowan Brown Rowan Brown true false 2cb3d1d96a7870a84d2f758e865172e6 0000-0002-4234-0033 Jeffrey Davies Jeffrey Davies true false 2022-03-01 FGMHL The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD. Journal Article Cellular and Molecular Neurobiology 43 Springer Science and Business Media LLC 0272-4340 1573-6830 Acyl-ghrelin, 6-OHDA, Parkinson’s disease 15 9 2022 2022-09-15 10.1007/s10571-022-01282-9 Brief Communication COLLEGE NANME Medicine, Health and Life Science - Faculty COLLEGE CODE FGMHL Swansea University SU Library paid the OA fee (TA Institutional Deal) Parkinson's UK, Grant number: K1008, K1008 2023-09-13T15:00:27.8162896 2022-03-01T10:38:26.0271035 Faculty of Medicine, Health and Life Sciences Swansea University Medical School - Medicine Amy Johnson 1 Daniel Rees 0000-0003-0372-6096 2 Amy Beynon 3 Mariah J. Lelos 0000-0001-7102-055x 4 Gaynor A. Smith 0000-0003-4332-8383 5 Luke Roberts 6 Lyndsey Phelps 7 Stephen B. Dunnett 0000-0003-1826-1578 8 Alwena Morgan 0000-0002-3441-5357 9 Rowan Brown 0000-0003-3628-2524 10 Timothy Wells 0000-0003-3618-0595 11 Jeffrey Davies 0000-0002-4234-0033 12 59475__22488__f355f9351f394952832a8a14a762b464.pdf 2022.01.31.478447v1.full.pdf 2022-03-01T10:47:29.7481034 Output 235025 application/pdf Pre-print true false 59475__25351__9a510e4c130f45738d2458f48ed48839.pdf 59475.VOR.pdf 2022-10-07T11:05:37.9591949 Output 1973930 application/pdf Version of Record true This article is licensed under a Creative Commons Attribution 4.0 International License. true eng http://creativecommons.org/licenses/by/4.0/
title Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
spellingShingle Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
Amy Johnson
Daniel Rees
Amy Beynon
Luke Roberts
Alwena Morgan
Rowan Brown
Jeffrey Davies
title_short Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
title_full Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
title_fullStr Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
title_full_unstemmed Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
title_sort Acyl-Ghrelin Attenuates Neurochemical and Motor Deficits in the 6-OHDA Model of Parkinson’s Disease
author_id_str_mv cd71e22a01d9a5d7e46cd8ef0fc28da1
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22576ee8492628137b76a5b8cb68a384
9ea39c3d0935c897cb9fcd3ba550af71
d7db8d42c476dfa69c15ce06d29bd863
2cb3d1d96a7870a84d2f758e865172e6
author_id_fullname_str_mv cd71e22a01d9a5d7e46cd8ef0fc28da1_***_Amy Johnson
daa6762111f9ebf62b9c2ec655512783_***_Daniel Rees
aefec476b7e8ca62f99c89dabd4bdf80_***_Amy Beynon
22576ee8492628137b76a5b8cb68a384_***_Luke Roberts
9ea39c3d0935c897cb9fcd3ba550af71_***_Alwena Morgan
d7db8d42c476dfa69c15ce06d29bd863_***_Rowan Brown
2cb3d1d96a7870a84d2f758e865172e6_***_Jeffrey Davies
author Amy Johnson
Daniel Rees
Amy Beynon
Luke Roberts
Alwena Morgan
Rowan Brown
Jeffrey Davies
author2 Amy Johnson
Daniel Rees
Amy Beynon
Mariah J. Lelos
Gaynor A. Smith
Luke Roberts
Lyndsey Phelps
Stephen B. Dunnett
Alwena Morgan
Rowan Brown
Timothy Wells
Jeffrey Davies
format Journal article
container_title Cellular and Molecular Neurobiology
container_volume 43
publishDate 2022
institution Swansea University
issn 0272-4340
1573-6830
doi_str_mv 10.1007/s10571-022-01282-9
publisher Springer Science and Business Media LLC
college_str Faculty of Medicine, Health and Life Sciences
hierarchytype
hierarchy_top_id facultyofmedicinehealthandlifesciences
hierarchy_top_title Faculty of Medicine, Health and Life Sciences
hierarchy_parent_id facultyofmedicinehealthandlifesciences
hierarchy_parent_title Faculty of Medicine, Health and Life Sciences
department_str Swansea University Medical School - Medicine{{{_:::_}}}Faculty of Medicine, Health and Life Sciences{{{_:::_}}}Swansea University Medical School - Medicine
document_store_str 1
active_str 0
description The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson’s disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD.
published_date 2022-09-15T15:00:29Z
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