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A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis
,
Paul J. Jarman,
Vanessa Hearnden,
Simon D Fairbanks,
Marcella Bassetto,
Hannes Maib,
John Palmer,
Kathryn R. Ayscough,
Jim A. Thomas ,
Carl Smythe
Angewandte Chemie International Edition, Volume: 61, Issue: 27, Start page: e202117449
Swansea University Authors:
Martin Gill , Marcella Bassetto
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DOI (Published version): 10.1002/anie.202117449
Abstract
The dinuclear RuII complex [(Ru(phen)2)2(tpphz)]4+ binds to G-actin monomers, preventing assembly into F-actin. This inhibits actin fibre assemblies within live cells and causes disruption to late cytokinesis by interfering with the function of endosomal sorting complexes required for transport (ESC...
| Published in: | Angewandte Chemie International Edition |
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| ISSN: | 1433-7851 1521-3773 |
| Published: |
Wiley
2022
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| Online Access: |
Check full text
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| URI: | https://cronfa.swan.ac.uk/Record/cronfa59895 |
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| Abstract: |
The dinuclear RuII complex [(Ru(phen)2)2(tpphz)]4+ binds to G-actin monomers, preventing assembly into F-actin. This inhibits actin fibre assemblies within live cells and causes disruption to late cytokinesis by interfering with the function of endosomal sorting complexes required for transport (ESCRT) during abscission. These results reveal new possibilities for metal complexes as biomedical tools and novel therapeutic leads. |
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| Keywords: |
Actin ;Cytokinesis; Cytoskeleton; Polypyridyl Complexes; Ruthenium |
| College: |
Faculty of Science and Engineering |
| Funders: |
Medical Research Council. Grant Number: R/162348 |
| Issue: |
27 |
| Start Page: |
e202117449 |