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Prescription of cardiovascular medication in children with congenital heart defects across six European Regions from 2000 to 2014: data from the EUROlinkCAT population-based cohort study

Mads Damkjaer Orcid Logo, Stine Kjaer Urhoj Orcid Logo, Joachim Tan, Gillian Briggs Orcid Logo, Maria Loane, Joanne Emma Given Orcid Logo, Laia Barrachina-Bonet, Clara Cavero-Carbonell Orcid Logo, Alessio Coi Orcid Logo, Amanda J Neville, Anna Heino, Sonja Kiuru-Kuhlefelt, Sue Jordan Orcid Logo, Ieuan Scanlon, Anna Pierini, Aurora Puccini, Ester Garne Orcid Logo, Joan K Morris Orcid Logo

BMJ Open, Volume: 12, Issue: 4, Start page: e057400

Swansea University Authors: Sue Jordan Orcid Logo, Ieuan Scanlon

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Abstract

Objectives Advances in surgical management strategies have substantially reduced fatality from congenital heart defects (CHD). Decreased infant mortality might be expected, consequentially to result in greater morbidity in older children due to complications later in childhood and adolescence. This...

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Published in: BMJ Open
ISSN: 2044-6055 2044-6055
Published: BMJ 2022
Online Access: Check full text

URI: https://cronfa.swan.ac.uk/Record/cronfa60078
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Abstract: Objectives Advances in surgical management strategies have substantially reduced fatality from congenital heart defects (CHD). Decreased infant mortality might be expected, consequentially to result in greater morbidity in older children due to complications later in childhood and adolescence. This study aims to evaluate the use of cardiovascular medication (CVM) as an indicator of disease burden in children born with CHD in the first 10 years of life.Design Population-based cohort study.Setting Six population-based registries from the European Surveillance of Congenital Anomalies (EUROCAT) network participated. Data from live born children with major congenital anomalies (CA) born from 2000 to 2014 were linked to prescription databases. Four groups of children were analysed: CA, CHD, severe CHD (sCHD) and ventricular septal defect (VSD) without sCHD. Live born children without CA were included as reference group.Participants We obtained data on 61 038 children born with a CA, including 19 678 with CHD, 3392 with sCHD, 12 728 children with VSD without sCHD, and 1 725 496 reference children.Results Children born with sCHD were the most likely to receive a CVM prescription (42.9%, 95% CI, 26.3 to 58.5) in the first year of life compared with 13.3% (6.7 to 22.0) of children with any CHD, 5.9% (3.7 to 8.7) of children with any CA and 0.1% (0.0 to 0.1) of reference children. Medication was less likely to be prescribed after the first year of life for sCHD; 18.8% (14.8 to 23.1) for children 1–4 years and 15.8% (12.0 to 20.1) 5–9 years. Children with sCHD were most likely to receive a diuretic (36.4%, 18.6 to 54.5), an antihypertensive (6.9%, 3.7 to 11.3) or a beta-blocker (5.5%, 2.9 to9.2).Conclusion Almost half of all children with sCHD were prescribed CVM in their first year of life. For all four groups of children with anomalies, the proportion of children with a CVM prescription decreased with age.
College: College of Human and Health Sciences
Funders: This study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733001.
Issue: 4
Start Page: e057400